Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/99145
Title: Idiopathic acute transverse myelitis: outcome and conversion to multiple sclerosis in a large series
Author: Cobo Calvo, Álvaro
Mañé Martínez, M. Alba
Alentorn Palau, Agustí
Bruna Escuer, Jordi
Romero Pinel, Lucía María
Martínez Yélamos, Sergio
Keywords: Esclerosi múltiple
Medul·la espinal
Inflamació
Diagnòstic
Multiple sclerosis
Spinal cord
Inflammation
Diagnosis
Issue Date: 3-Oct-2013
Publisher: BioMed Central
Abstract: Background: in 2002, the Transverse Myelitis Consortium Working Group (TMCWG) proposed the diagnostic criteria for idiopathic acute transverse myelitis (IATM) to delimit and unify this group of patients. This study aimed to describe the conversion rate to multiple sclerosis (MS) and variables associated with conversion, and to analyze functional outcome and prognostic factors associated with functional recovery in patients who fulfilled the current TMCWG criteria for definite and possible IATM. Methods: eighty-seven patients diagnosed with IATM between 1989 and 2011 were retrospectively reviewed. Two patients with positive neuromyelitis optica IgG serum antibodies were excluded. Epidemiological, clinical, laboratory, magnetic resonance imaging (MRI) data and outcome of 85 patients were analyzed. Results: eleven (13%) patients converted to MS after a median follow-up of 2.9 years (interquartile range 1.0-4.8). Early-age onset of symptoms was related to conversion to MS. Only 9.4% of patients with IATM were unable to walk unassisted at the end of follow-up. Urinary sphincter dysfunction (odds ratio [OR] 3.37, 95% confidence interval [CI] 1.04-10.92) and longitudinally extensive transverse myelitis (LETM) on MRI (OR 12.34, 95% CI 3.38-45.00) were associated with a poorer outcome (Rankin ≥ 2). Conclusions: at least 13% of patients who fulfill the TMCWG criteria for definite and possible IATM will convert to MS. Functional recovery in IATM is poorer in patients with urinary sphincter dysfunction at admission or LETM on MRI.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1186/1471-2377-13-135
It is part of: BMC Neurology, 2013, vol. 13, p. 135
Related resource: http://dx.doi.org/10.1186/1471-2377-13-135
URI: http://hdl.handle.net/2445/99145
ISSN: 1471-2377
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
653781.pdf340.59 kBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons