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Title: Total Synthesis of (+)-Madangamine D
Author: Ballette, Roberto
Pérez Bosch, Maria
Proto, Stefano
Amat Tusón, Mercedes
Bosch Cartes, Joan
Keywords: Farmacologia
Productes naturals marins
Marine natural products
Issue Date: 2-May-2014
Publisher: Wiley-VCH
Abstract: Madangamines are a group of bioactive marine sponge alkaloids, embodying an unprecedented diazapentacyclic skeletal type. The enantioselective total synthesis of madangamine D has been accomplished, and represents the first total synthesis of an alkaloid of the madangamine group. It involves the stereoselective construction of the diazatricyclic ABC core using a phenylglycinol-derived lactam as the starting enantiomeric scaffold and the subsequent assembly of the peripheral macrocyclic rings. The synthesis provides, for the first time, a pure sample of madangamine D and confirms the absolute configuration of this alkaloid family.
Note: Versió postprint del document publicat a:
It is part of: Angewandte Chemie-International Edition, 2014, vol. 53, num. 24, p. 6202-6205
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ISSN: 1433-7851
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

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