Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/99513
Title: High prevalence of Pneumocystis jirovecii pneumonia among Mozambican children < 5 years of age admitted to hospital with clinical severe pneumonia
Author: Lanaspa, Miguel
O'Callaghan Gordo, Cristina
Machevo, Sonia
Madrid, Lola
Nhampossa, Tacilta
Acácio, Sozinho
Horra, C. de la
Friaza, V.
Campano, E.
Alonso, Pedro
Calderon, E.
Roca, A.
Bassat Orellana, Quique
Keywords: Pneumònia
Infants
Pneumonia
Children
Issue Date: 28-Jul-2015
Publisher: Elsevier
Abstract: We aimed to describe Pneumocystis jirovecii pneumonia (PCP) prevalence and features in children from sub-Saharan Africa, and to investigate PCP-associated risk factors. During 2006-2007 we used molecular methods to test children younger than 5 years old admitted with severe pneumonia to a hospital in Southern Mozambique for Pneumocystis infection. We recruited 834 children. PCP prevalence was 6.8% and HIV prevalence was 25.7%. The in-hospital and delayed mortality were significantly higher among children with PCP (20.8% vs. 10.2 %, p=0.021, and 11.5% vs. 3.6%, p=0.044, respectively). Clinical features were mostly overlapping between the two groups. Independent risk factors for PCP were age less than a year (OR 6.34, 95%CI 1.86-21.65), HIV infection (OR 2.99, 95%CI 1.16-7.70), grunting (OR 2.64, 95%CI 1.04-6.73), and digital clubbing (OR 10.75, 95%CI 1.21-95.56). PCP is a common and life-threatening cause of severe pneumonia in Mozambican children. Mother-to-child HIV transmission prevention should be strengthened. Better diagnostic tools are needed.
Note: Versió postprint del document publicat a: http://dx.doi.org/10.1016/j.cmi.2015.07.011
It is part of: Clinical Microbiology and Infection, 2015, vol. 21, num. 11, p. 1018.e9–1018.e15
Related resource: http://dx.doi.org/10.1016/j.cmi.2015.07.011
URI: http://hdl.handle.net/2445/99513
ISSN: 1198-743X
Appears in Collections:Articles publicats en revistes (ISGlobal)

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