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Title: Polyamidoamine nanoparticles as nanocarriers for the drug delivery to malaria parasite stages in the mosquito vector
Author: Urbán, Patricia
Ranucci, Elisabetta
Fernàndez Busquets, Xavier
Keywords: Malària
Malalties parasitàries
Parasitic diseases
Issue Date: Nov-2015
Publisher: Future Medicine
Abstract: Malaria is arguably one of the main medical concerns worldwide because of the numbers of people affected, the severity of the disease and the complexity of the life cycle of its causative agent, the protist Plasmodium spp. With the advent of nanoscience, renewed hopes have appeared of finally obtaining the long sought-after magic bullet against malaria in the form of a nanovector for the targeted delivery of antimalarial compounds exclusively to Plasmodium-infected cells, thus increasing drug efficacy and minimizing the induction of resistance to newly developed therapeutic agents. Polyamidoamine-derived nanovectors combine into a single chemical structure drug encapsulating capacity, antimalarial activity, low unspecific toxicity, specific targeting to Plasmodium, optimal in vivo activity and affordable synthesis cost. After having shown their efficacy in targeting drugs to intraerythrocytic parasites, now polyamidoamines face the challenge of spearheading a new generation of nanocarriers aiming at the malaria parasite stages in the mosquito vector.
Note: Versió postprint del document publicat a:
It is part of: Nanomedicine, 2015, vol. 10, num. 22, p. 3401-3414
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ISSN: 1743-5889
Appears in Collections:Articles publicats en revistes (ISGlobal)

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