Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/99600
Title: Phylogenomic Evidence for a Myxococcal Contribution to the Mitochondrial Fatty Acid Beta-Oxidation
Author: Schlüter, A.
Ruiz Trillo, Iñaki
Pujol, A.
Keywords: Mitocondris
Àcids grassos
Mitochondria
Fatty acids
Issue Date: 7-Jul-2011
Publisher: Public Library of Science (PLoS)
Abstract: Background The origin of eukaryotes remains a fundamental question in evolutionary biology. Although it is clear that eukaryotic genomes are a chimeric combination of genes of eubacterial and archaebacterial ancestry, the specific ancestry of most eubacterial genes is still unknown. The growing availability of microbial genomes offers the possibility of analyzing the ancestry of eukaryotic genomes and testing previous hypotheses on their origins. Methodology/Principal Findings Here, we have applied a phylogenomic analysis to investigate a possible contribution of the Myxococcales to the first eukaryotes. We conducted a conservative pipeline with homologous sequence searches against a genomic sampling of 40 eukaryotic and 357 prokaryotic genomes. The phylogenetic reconstruction showed that several eukaryotic proteins traced to Myxococcales. Most of these proteins were associated with mitochondrial lipid intermediate pathways, particularly enzymes generating reducing equivalents with pivotal roles in fatty acid β-oxidation metabolism. Our data suggest that myxococcal species with the ability to oxidize fatty acids transferred several genes to eubacteria that eventually gave rise to the mitochondrial ancestor. Later, the eukaryotic nucleocytoplasmic lineage acquired those metabolic genes through endosymbiotic gene transfer. Conclusions/Significance Our results support a prokaryotic origin, different from α-proteobacteria, for several mitochondrial genes. Our data reinforce a fluid prokaryotic chromosome model in which the mitochondrion appears to be an important entry point for myxococcal genes to enter
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0021989
It is part of: PLoS One, 2011, vol. 6, num. 7, p. e21989
URI: http://hdl.handle.net/2445/99600
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Publicacions de projectes de recerca finançats per la UE

Files in This Item:
File Description SizeFormat 
629326.pdf518.12 kBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons