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Title: Zebrafish models for human acute organophosphorus poisoning
Author: Faria, Melissa
Garcia-Reyero, Natàlia
Padrós, Francesc
Babin, Patrick J.
Sebastián Muñoz, David
Cachot, Jérôme
Prats, Eva
Arick II, Mark
Rial, Eduardo
Knoll-Gellida, Anja
Mathieu, Guilaine
Le Bihanic, Florane
Escalon, B. Lynn
Zorzano Olarte, Antonio
Soares, Amadeu M.V.M
Raldúa, Demetrio
Keywords: Toxicologia
Armes químiques
Chemical weapons
Issue Date: 22-Oct-2015
Publisher: Nature Publishing Group
Abstract: Terrorist use of organophosphorus-based nerve agents and toxic industrial chemicals against civilian populations constitutes a real threat, as demonstrated by the terrorist attacks in Japan in the 1990 s or, even more recently, in the Syrian civil war. Thus, development of more effective countermeasures against acute organophosphorus poisoning is urgently needed. Here, we have generated and validated zebrafish models for mild, moderate and severe acute organophosphorus poisoning by exposing zebrafish larvae to different concentrations of the prototypic organophosphorus compound chlorpyrifos-oxon. Our results show that zebrafish models mimic most of the pathophysiological mechanisms behind this toxidrome in humans, including acetylcholinesterase inhibition, N-methyl-D-aspartate receptor activation, and calcium dysregulation as well as inflammatory and immune responses. The suitability of the zebrafish larvae to in vivo high-throughput screenings of small molecule libraries makes these models a valuable tool for identifying new drugs for multifunctional drug therapy against acute organophosphorus poisoning.
Note: Reproducció del document publicat a:
It is part of: Scientific Reports, 2015, vol. 5, num. 15591
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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