Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/99682
Title: The Burden of Cryptosporidium Diarrheal Disease among Children < 24 Months of Age in Moderate/High Mortality Regions of Sub-Saharan Africa and South Asia, Utilizing Data from the Global Enteric Multicenter Study (GEMS).
Author: Sow, Samba O.
Muhsen, Khitam
Nasrin, Dilruba
Blackwelder, William C.
Wu, Yukun
Farag, Tamer H.
Panchalingam, Sandra
Sur, Dipika
Zaidi, Anita K. M.
Faruque, Abu S. G.
Saha, Debasish
Adegbola, Richard
Alonso, Pedro
Breiman, Robert F.
Bassat Orellana, Quique
Tamboura, Boubou
Sanogo, Doh
Onwuchekwa, Uma
Manna, Byomkesh
Ramamurthy, Thandavarayan
Kanungo, Suman
Ahmed, Shahnawaz
Qureshi, Shahida
Quadri, Farheen
Hossain, Anowar
Das, Sumon K.
Antonio, Martin
Hossain, M. Jahangir
Mandomando, Inácio
Nhampossa, Tacilta
Acácio, Sozinho
Omore, Richard
Oundo, Joseph O.
Ochieng, John B.
O’Reilly, Ciara E.
Berkeley, Lynette Y.
Livio, Sofie
Tennant, Sharon M.
Sommerfelt, Halvor
Nataro, James P.
Ziv-Baran, Tomer
Robins-Browne, Roy M.
Mishcherkin, Vladimir
Zhang, Jixian
Liu, Jie
Houpt, Eric R.
Kotloff, Karen L.
Levine, Myron M.
Mintz, Eric D.
Keywords: Diarrea
Infants
Diarrhea
Children
Issue Date: 24-May-2016
Publisher: Public Library of Science (PLoS)
Abstract: Background: The importance of Cryptosporidium as a pediatric enteropathogen in developing countries is recognized. Methods: Data from the Global Enteric Multicenter Study (GEMS), a 3-year, 7-site, case-control study of moderate-to-severe diarrhea (MSD) and GEMS-1A (1-year study of MSD and less-severe diarrhea [LSD]) were analyzed. Stools from 12,110 MSD and 3,174 LSD cases among children aged <60 months and from 21,527 randomly-selected controls matched by age, sex and community were immunoassay-tested for Cryptosporidium. Species of a subset of Cryptosporidium-positive specimens were identified by PCR; GP60 sequencing identified anthroponotic C. parvum. Combined annual Cryptosporidium-attributable diarrhea incidences among children aged <24 months for African and Asian GEMS sites were extrapolated to sub-Saharan Africa and South Asian regions to estimate region-wide MSD and LSD burdens. Attributable and excess mortality due to Cryptosporidium diarrhea were estimated. Findings: Cryptosporidium was significantly associated with MSD and LSD below age 24 months. Among Cryptosporidium-positive MSD cases, C. hominis was detected in 77.8% (95% CI, 73.0%-81.9%) and C. parvum in 9.9% (95% CI, 7.1%-13.6%); 92% of C. parvum tested were anthroponotic genotypes. Annual Cryptosporidium-attributable MSD incidence was 3.48 (95% CI, 2.27–4.67) and 3.18 (95% CI, 1.85–4.52) per 100 child-years in African and Asian infants, respectively, and 1.41 (95% CI, 0.73–2.08) and 1.36 (95% CI, 0.66–2.05) per 100 child-years in toddlers. Corresponding Cryptosporidium-attributable LSD incidences per 100 child-years were 2.52 (95% CI, 0.33–5.01) and 4.88 (95% CI, 0.82–8.92) in infants and 4.04 (95% CI, 0.56–7.51) and 4.71 (95% CI, 0.24–9.18) in toddlers. We estimate 2.9 and 4.7 million Cryptosporidium-attributable cases annually in children aged <24 months in the sub-Saharan Africa and India/Pakistan/Bangladesh/Nepal/Afghanistan regions, respectively, and ~202,000 Cryptosporidium-attributable deaths (regions combined). ~59,000 excess deaths occurred among Cryptosporidium-attributable diarrhea cases over expected if cases had been Cryptosporidium-negative. Conclusions: The enormous African/Asian Cryptosporidium disease burden warrants investments to develop vaccines, diagnostics and therapies.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pntd.0004729
It is part of: PLoS Neglected Tropical Diseases, 2016, vol. 10, num. 5, p. e0004729
Related resource: http://dx.doi.org/10.1371/journal.pntd.0004729
URI: http://hdl.handle.net/2445/99682
ISSN: 1935-2735
Appears in Collections:Articles publicats en revistes (ISGlobal)

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