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Title: Hypoglycemia and Risk Factors for Death in 13 Years of Pediatric Admissions in Mozambique
Author: Madrid, Lola
Acácio, Sozinho
Nhampossa, Tacilta
Lanaspa, Miguel
Sitoe, Antonio
Maculuve, Sónia Amós
Mucavele, Helio
Quintó, Llorenç
Sigaúque, Betuel
Bassat Orellana, Quique
Keywords: Hipoglucèmia
Issue Date: 26-Oct-2015
Publisher: American Society of Tropical Medicine and Hygiene
Abstract: Hypoglycemia is a life-threatening complication of several diseases in childhood. We describe the prevalence and incidence of hypoglycemia among admitted Mozambican children, establishing its associated risk factors. We retrospectively reviewed clinical data of 13 years collected through an ongoing systematic morbidity surveillance in Manhica District Hospital in rural Mozambique. Logistic regression was used to identify risk factors for hypoglycemia and death. Minimum community-based incidence rates (MCBIRs) for hypoglycemia were calculated using data from the demographic surveillance system. Of 49,089 children < 15 years hospitalized in Manhica District Hospital, 45,573 (92.8%) had a glycemia assessment on admission. A total of 1,478 children (3.2%) presented hypoglycemia (< 3 mmol/L), of which about two-thirds (972) were with levels < 2.5 mmol/L. Independent risk factors for hypoglycemia on admission and death among hypoglycemic children included prostration, unconsciousness, edema, malnutrition, and bacteremia. Hypoglycemic children were significantly more likely to die (odds ratio [OR] = 7.11; P < 0.001), with an associated case fatality rate (CFR) of 19.3% (245/1,267). Overall MCBIR of hypoglycemia was 1.57 episodes/1,000 child years at risk (CYAR), significantly decreasing throughout the study period. Newborns showed the highest incidences (9.47 episodes/1,000 CYAR, P < 0.001). Hypoglycemia remains a hazardous condition for African children. Symptoms and signs associated to hypoglycemia should trigger the verification of glycemia and the implementation of life-saving corrective measures.
Note: Versió postprint del document publicat a:
It is part of: The American Journal of Tropical Medicine and Hygiene, 2016, vol. 94, num. 1, p.
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ISSN: 0002-9637
Appears in Collections:Articles publicats en revistes (ISGlobal)

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