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Title: | Hypoglycemia and Risk Factors for Death in 13 Years of Pediatric Admissions in Mozambique |
Author: | Madrid, Lola Acácio, Sozinho Nhampossa, Tacilta Lanaspa, Miguel Sitoe, Antonio Maculuve, Sónia Amós Mucavele, Helio Quintó, Llorenç Sigaúque, Betuel Bassat Orellana, Quique |
Keywords: | Hipoglucèmia Moçambic Hypoglycemia Mozambique |
Issue Date: | 26-Oct-2015 |
Publisher: | American Society of Tropical Medicine and Hygiene |
Abstract: | Hypoglycemia is a life-threatening complication of several diseases in childhood. We describe the prevalence and incidence of hypoglycemia among admitted Mozambican children, establishing its associated risk factors. We retrospectively reviewed clinical data of 13 years collected through an ongoing systematic morbidity surveillance in Manhica District Hospital in rural Mozambique. Logistic regression was used to identify risk factors for hypoglycemia and death. Minimum community-based incidence rates (MCBIRs) for hypoglycemia were calculated using data from the demographic surveillance system. Of 49,089 children < 15 years hospitalized in Manhica District Hospital, 45,573 (92.8%) had a glycemia assessment on admission. A total of 1,478 children (3.2%) presented hypoglycemia (< 3 mmol/L), of which about two-thirds (972) were with levels < 2.5 mmol/L. Independent risk factors for hypoglycemia on admission and death among hypoglycemic children included prostration, unconsciousness, edema, malnutrition, and bacteremia. Hypoglycemic children were significantly more likely to die (odds ratio [OR] = 7.11; P < 0.001), with an associated case fatality rate (CFR) of 19.3% (245/1,267). Overall MCBIR of hypoglycemia was 1.57 episodes/1,000 child years at risk (CYAR), significantly decreasing throughout the study period. Newborns showed the highest incidences (9.47 episodes/1,000 CYAR, P < 0.001). Hypoglycemia remains a hazardous condition for African children. Symptoms and signs associated to hypoglycemia should trigger the verification of glycemia and the implementation of life-saving corrective measures. |
Note: | Versió postprint del document publicat a: http://dx.doi.org/10.4269/ajtmh.15-0475 |
It is part of: | The American Journal of Tropical Medicine and Hygiene, 2016, vol. 94, num. 1, p. |
URI: | http://hdl.handle.net/2445/99686 |
Related resource: | http://dx.doi.org/10.4269/ajtmh.15-0475 |
ISSN: | 0002-9637 |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
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madrid2016_2001.pdf | 412.5 kB | Adobe PDF | View/Open |
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