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Title: | Mitogen-activated protein kinases and mitogen kinase phosphatase 1: a critical interplay in macrophage biology |
Author: | Lloberas Cavero, Jorge Valverde Estrella, Lorena Tur Torres, Juan Vico Rivero, Tania Celada Cotarelo, Antonio |
Keywords: | Enzims Macròfags Esterases Enzymes Macrophages Esterases |
Issue Date: | 28-Jun-2016 |
Publisher: | Frontiers Media |
Abstract: | Macrophages are necessary in multiple processes during the immune response or inflammation. This review emphasizes the critical role of the mitogen-activated protein kinases (MAPKs) and mitogen kinase phosphatase-1 (MKP-1) in the functional activities of macrophages. While the phosphorylation of MAPKs is required for macrophage activation or proliferation, MKP-1 dephosphorylates these kinases, thus playing a balancing role in the control of macrophage behavior. MKP-1 is a nuclear-localized dual-specificity phosphatase whose expression is regulated at multiple levels, including at the transcriptional and post-transcriptional level. The regulatory role of MKP-1 in the interplay between MAPK phosphorylation/dephosphorylation makes this molecule a critical regulator of macrophage biology and inflammation. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.3389/fmolb.2016.00028 |
It is part of: | Frontiers in Immunology, 2016, vol. 3, p. 1-8 |
URI: | http://hdl.handle.net/2445/100209 |
Related resource: | http://dx.doi.org/10.3389/fmolb.2016.00028 |
Appears in Collections: | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) |
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