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DC Field | Value | Language |
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dc.contributor.author | Garcia-Etxebarria, Koldo | - |
dc.contributor.author | Bracho, María Alma | - |
dc.contributor.author | Galán, Juan Carlos | - |
dc.contributor.author | Pumarola Suñé, Tomàs | - |
dc.contributor.author | Castilla, Jesús | - |
dc.contributor.author | Ortiz de Lejarazu, Raul | - |
dc.contributor.author | Rodríguez-Dominguez, Mario | - |
dc.contributor.author | Quintela, Inés | - |
dc.contributor.author | Bonet, Núria | - |
dc.contributor.author | Garcia-Garcerà, Marc | - |
dc.contributor.author | Domínguez García, Àngela | - |
dc.contributor.author | González-Candelas, Fernando | - |
dc.contributor.author | Calafell, Francesc | - |
dc.date.accessioned | 2016-07-15T10:34:24Z | - |
dc.date.available | 2016-07-15T10:34:24Z | - |
dc.date.issued | 2015-09-17 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/100545 | - |
dc.description.abstract | While most patients affected by the influenza A(H1N1) pandemic experienced mild symptoms, a small fraction required hospitalization, often without concomitant factors that could explain such a severe course. We hypothesize that host genetic factors could contribute to aggravate the disease. To test this hypothesis, we compared the allele frequencies of 547,296 genome-wide single nucleotide polymorphisms (SNPs) between 49 severe and 107 mild confirmed influenza A cases, as well as against a general population sample of 549 individuals. When comparing severe vs. mild influenza A cases, only one SNP was close to the conventional p = 5×10−8. This SNP, rs28454025, sits in an intron of the GSK233 gene, which is involved in a neural development, but seems not to have any connections with immunological or inflammatory functions. Indirectly, a previous association reported with CD55 was replicated. Although sample sizes are low, we show that the statistical power in our design was sufficient to detect highly-penetrant, quasi-Mendelian genetic factors. Hence, and assuming that rs28454025 is likely to be a false positive, no major genetic factor was detected that could explain poor influenza A course. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0135983 | - |
dc.relation.ispartof | PLoS One, 2015, vol. 10, num. 9, p. e0135983 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0135983 | - |
dc.rights | cc-by (c) Garcia-Etxebarria, K. et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Grip | - |
dc.subject.classification | Genòmica | - |
dc.subject.classification | Factors de risc en les malalties | - |
dc.subject.classification | Estudi de casos | - |
dc.subject.other | Influenza | - |
dc.subject.other | Genomics | - |
dc.subject.other | Risk factors in diseases | - |
dc.subject.other | Case studies | - |
dc.title | No major host genetic risk factor contributed to A(H1N1)2009 influenza severity | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 658361 | - |
dc.date.updated | 2016-07-15T10:34:29Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26379185 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
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658361.pdf | 1.53 MB | Adobe PDF | View/Open |
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