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http://hdl.handle.net/2445/101480
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DC Field | Value | Language |
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dc.contributor.author | Selva Jové, Laura | - |
dc.contributor.author | Ciruela, Pilar | - |
dc.contributor.author | Blanchette, Krystle | - |
dc.contributor.author | Amo Moran, Eva del | - |
dc.contributor.author | Pallarés Giner, Roman | - |
dc.contributor.author | Orihuela, Carlos J. | - |
dc.contributor.author | Muñoz-Almagro, Carmen | - |
dc.date.accessioned | 2016-08-31T11:01:23Z | - |
dc.date.available | 2016-08-31T11:01:23Z | - |
dc.date.issued | 2012-07-25 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/101480 | - |
dc.description.abstract | Streptococcus pneumoniae is the leading cause of vaccine-preventable deaths globally. The objective of this study was to determine the distribution and clonal type variability of three potential vaccine antigens: Pneumococcal serine-rich repeat protein (PsrP), Pilus-1, and Pneumococcal choline binding protein A (PcpA) among pneumococcal isolates from children with invasive pneumococcal disease and healthy nasopharyngeal carriers. We studied by Real-Time PCR a total of 458 invasive pneumococcal isolates and 89 nasopharyngeal pneumococcal isolates among children (total = 547 strains) collected in Barcelona, Spain, from January 2004 to July 2010. pcpA, psrP and pilus-1 were detected in 92.8%, 51.7% and 14.4% of invasive isolates and in 92.1%, 48.3% and 18% of carrier isolates, respectively. Within individual serotypes the prevalence of psrP and pilus-1 was highly dependent on the clonal type. pcpA was highly prevalent in all strains with the exception of those belonging to serotype 3 (33.3% in serotype 3 isolates vs. 95.1% in other serotypes; P<.001). psrP was significantly more frequent in those serotypes that are less apt to be detected in carriage than in disease; 58.7% vs. 39.1% P<.001. Antibiotic resistance was associated with the presence of pilus-1 and showed a negative correlation with psrP. These results indicate that PcpA, and subsequently Psrp and Pilus-1 together might be good candidates to be used in a next-generation of multivalent pneumococcal protein vaccine. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0041587 | - |
dc.relation.ispartof | PLoS One, 2012, vol. 7, num. 7, p. e41587 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0041587 | - |
dc.rights | cc-by (c) Selva Jové, Laura et al., 2012 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Pneumococs | - |
dc.subject.classification | Infeccions per pneumococs | - |
dc.subject.classification | Vacuna antipneumocòccica | - |
dc.subject.classification | Vacunes | - |
dc.subject.classification | Vacunació dels infants | - |
dc.subject.classification | Resistència als medicaments | - |
dc.subject.classification | Pediatria | - |
dc.subject.other | Streptococcus pneumonia | - |
dc.subject.other | Pneumococcal Infections | - |
dc.subject.other | Pneumococcal vaccine | - |
dc.subject.other | Vaccines | - |
dc.subject.other | Vaccination of children | - |
dc.subject.other | Drug resistance | - |
dc.subject.other | Pediatrics | - |
dc.title | Prevalence and clonal distribution of pcpA, psrP and Pilus-1 among pediatric isolates of Streptococcus pneumoniae | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 640991 | - |
dc.date.updated | 2016-08-31T11:01:28Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 22848535 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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640991.pdf | 359.03 kB | Adobe PDF | View/Open |
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