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http://hdl.handle.net/2445/101571
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DC Field | Value | Language |
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dc.contributor.author | Ramírez-Mena, Adrià | - |
dc.contributor.author | Glass, Tracy R. | - |
dc.contributor.author | Winter, Annja | - |
dc.contributor.author | Kimera, Namvua | - |
dc.contributor.author | Ntamatungiro, Alex J. | - |
dc.contributor.author | Hatz, Christoph | - |
dc.contributor.author | Tanner, Marcel | - |
dc.contributor.author | Battegay, Manuel | - |
dc.contributor.author | Furrer, Hansjakob | - |
dc.contributor.author | Wandeler, Gilles | - |
dc.contributor.author | Letang, Emilio | - |
dc.contributor.author | KIULARCO Study Group | - |
dc.date.accessioned | 2016-09-06T06:59:01Z | - |
dc.date.available | 2016-09-06T06:59:01Z | - |
dc.date.issued | 2016-07-29 | - |
dc.identifier.issn | 2328-8957 | - |
dc.identifier.uri | http://hdl.handle.net/2445/101571 | - |
dc.description.abstract | Background. We evaluated the prevalence of chronic hepatitis B virus (HBV) infection and liver fibrosis/cirrhosis in human immunodeficiency virus (HIV)-infected individuals enrolled in a rural Tanzanian prospective cohort and assessed hepatic fibrosis progression 12–24 months after antiretroviral treatment (ART) initiation. Methods. All ART-naive HIV-infected adults ≥15-year-old enrolled in the Kilombero and Ulanga Antiretroviral Cohort who started ART between 2005 and 2015 were included. Pre-ART factors associated with significant liver fibrosis (aspartate aminotransferase-to-platelet ratio index [APRI] >1.5) and cirrhosis (APRI > 2.0) were identified using logistic regression. Results. Of 3097 individuals screened, 227 (7.3%; 95% CI, 6.4–8.2) were hepatitis B surface antigen (HBsAg) positive. Before ART initiation, 9.1% individuals had significant liver fibrosis and 5.3% had cirrhosis. Human immunodeficiency virus/HBVcoinfected individuals were more likely to have an APRI score indicating significant fibrosis (14.2% vs 8.7%, P = .03) and cirrhosis (9.2% vs 4.9%, P = .03) than HBV-uninfected patients. CD4 cell count <200 cell/μL and alcohol consumption were independently associated with pre-ART APRI score, indicating significant fibrosis and cirrhosis in multivariable analyses. Among individuals with elevated APRI measurements pre- and 12–24 months post-ART initiation, 53 of 57 (93.0%) of HIV-monoinfected and 4 of 5 (80.0%) of HIV/HBV-coinfected had a regression to APRI < 1.5. Conclusions. Hepatic fibrosis and cirrhosis were common in our cohort, especially among HIV/HBV-coinfected individuals. The APRI improved in most patients. Pre-ART HBsAg screening and early onset of tenofovir-based ART for HIV/HBV-coinfection should be prioritized in sub-Saharan Africa. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1093/ofid/ofw162 | - |
dc.relation.ispartof | Open Forum Infectious Diseases, 2016, vol. 3, num. 3 | - |
dc.relation.uri | http://dx.doi.org/10.1093/ofid/ofw162 | - |
dc.rights | (c) Ramírez-Mena et al., 2016 | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | Virus de l'hepatitis B | - |
dc.subject.classification | VIH (Virus) | - |
dc.subject.classification | Tanzània | - |
dc.subject.other | Hepatitis B virus | - |
dc.subject.other | HIV (Viruses) | - |
dc.subject.other | Tanzania | - |
dc.title | Prevalence and Outcomes of Hepatitis B Co-infection and Associated Liver Disease Among Antiretroviral Therapy-Naive Individuals in a Rural Tanzanian Human Immunodeficiency Virus Cohort | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2016-08-10T18:00:49Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27704017 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
Files in This Item:
File | Description | Size | Format | |
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Open Forum Infect Dis-2016-Ramírez-Mena-.pdf | 229.65 kB | Adobe PDF | View/Open |
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