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http://hdl.handle.net/2445/102127
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DC Field | Value | Language |
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dc.contributor.author | Li, Shunqiang | - |
dc.contributor.author | Shen, Dong | - |
dc.contributor.author | Shao, Jieya | - |
dc.contributor.author | Crowder, Robert | - |
dc.contributor.author | Liu, Wenbin | - |
dc.contributor.author | Prat Aparicio, Aleix | - |
dc.contributor.author | He, Xiaping | - |
dc.contributor.author | Liu, Shuying | - |
dc.contributor.author | Hoog, Jeremy | - |
dc.contributor.author | Lu, Charles | - |
dc.contributor.author | Ding, Li | - |
dc.contributor.author | Griffith, Obi L. | - |
dc.contributor.author | Miller, Christopher | - |
dc.contributor.author | Larson, Dave | - |
dc.contributor.author | Fulton, Robert S. | - |
dc.contributor.author | Harrison, Michelle | - |
dc.contributor.author | Mooney, Tom | - |
dc.contributor.author | McMichael, Joshua F. | - |
dc.contributor.author | Luo, Jingqin | - |
dc.contributor.author | Tao, Yu | - |
dc.contributor.author | Goncalves, Rodrigo | - |
dc.contributor.author | Schlosberg, Christopher | - |
dc.contributor.author | Hiken, Jeffrey F. | - |
dc.contributor.author | Saied, Laila | - |
dc.contributor.author | Sanchez, Cesar | - |
dc.contributor.author | Giuntoli, Therese | - |
dc.contributor.author | Bumb, Caroline | - |
dc.contributor.author | Cooper, Crystal | - |
dc.contributor.author | Kitchens, Robert T. | - |
dc.contributor.author | Lin, Aaustin | - |
dc.contributor.author | Phommaly, Chanpheng | - |
dc.contributor.author | Davies, Sherri R. | - |
dc.contributor.author | Zhang, Jim | - |
dc.contributor.author | Kavuri, Megha Shyam | - |
dc.contributor.author | McEachern, Donna | - |
dc.contributor.author | Dong, Yi Yu | - |
dc.contributor.author | Ma, Cynthia X. | - |
dc.contributor.author | Pluard, Timothy | - |
dc.contributor.author | Naughton, Michael | - |
dc.contributor.author | Bose, Ron | - |
dc.date.accessioned | 2016-09-26T07:49:53Z | - |
dc.date.available | 2016-09-26T07:49:53Z | - |
dc.date.issued | 2013-09-19 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | http://hdl.handle.net/2445/102127 | - |
dc.description.abstract | To characterize patient-derived xenografts (PDXs) for functional studies, we made whole-genome comparisons with originating breast cancers representative of the major intrinsic subtypes. Structural and copy number aberrations were found to be retained with high fidelity. However, at the single-nucleotide level, variable numbers of PDX-specific somatic events were documented, although they were only rarely functionally significant. Variant allele frequencies were often preserved in the PDXs, demonstrating that clonal representation can be transplantable. Estrogen-receptor-positive PDXs were associated with ESR1 ligand-binding-domain mutations, gene amplification, or an ESR1/YAP1 translocation. These events produced different endocrine-therapy-response phenotypes in human, cell line, and PDX endocrine-response studies. Hence, deeply sequenced PDX models are an important resource for the search for genome-forward treatment options and capture endocrine-drug-resistance etiologies that are not observed in standard cell lines. The originating tumor genome provides a benchmark for assessing genetic drift and clonal representation after transplantation. | - |
dc.format.extent | 28 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1016/j.celrep.2013.08.022 | - |
dc.relation.ispartof | Cell Reports, 2013, vol. 4, num. 6, p. 1116-1130 | - |
dc.relation.uri | http://dx.doi.org/10.1016/j.celrep.2013.08.022 | - |
dc.rights | cc-by (c) Li, S. et al., 2013 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Càncer de mama | - |
dc.subject.classification | Genòmica | - |
dc.subject.classification | Biologia molecular | - |
dc.subject.classification | Estudi de casos | - |
dc.subject.other | Breast cancer | - |
dc.subject.other | Genomics | - |
dc.subject.other | Molecular biology | - |
dc.subject.other | Case studies | - |
dc.title | Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 662592 | - |
dc.date.updated | 2016-09-26T07:49:59Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 24055055 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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File | Description | Size | Format | |
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662592.pdf | 3.41 MB | Adobe PDF | View/Open |
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