Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/102376
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DC Field | Value | Language |
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dc.contributor.author | Xu, Keli | - |
dc.contributor.author | Usary, Jerry | - |
dc.contributor.author | Kousis, Philaretos C. | - |
dc.contributor.author | Prat Aparicio, Aleix | - |
dc.contributor.author | Wang, Dong-Yu | - |
dc.contributor.author | Adams, Jessica R. | - |
dc.contributor.author | Wang, Wei | - |
dc.contributor.author | Loch, Amanda J. | - |
dc.contributor.author | Deng, Tao | - |
dc.contributor.author | Zhao, Wei | - |
dc.contributor.author | Cardiff, Robert D. | - |
dc.contributor.author | Yoon, Keejung | - |
dc.contributor.author | Gaiano, Nicholas | - |
dc.contributor.author | Ling, Vicki | - |
dc.contributor.author | Beyene, Joseph | - |
dc.contributor.author | Zacksenhaus, Eldad | - |
dc.contributor.author | Gridley, Tom | - |
dc.contributor.author | Leong, Wey L. | - |
dc.contributor.author | Guidos, Cynthia | - |
dc.contributor.author | Perou, Charles M. | - |
dc.contributor.author | Egan, Sean E. | - |
dc.date.accessioned | 2016-10-05T07:54:27Z | - |
dc.date.available | 2016-10-05T07:54:27Z | - |
dc.date.issued | 2012-05-15 | - |
dc.identifier.issn | 1535-6108 | - |
dc.identifier.uri | http://hdl.handle.net/2445/102376 | - |
dc.description.abstract | Basal-like breast cancers (BLBC) express a luminal progenitor gene signature. Notch receptor signaling promotes luminal cell fate specification in the mammary gland, while suppressing stem cell self-renewal. Here we show that deletion of Lfng, a sugar transferase that prevents Notch activation by Jagged ligands, enhances stem/progenitor cell proliferation. Mammary-specific deletion of Lfng induces basal-like and claudin-low tumors with accumulation of Notch intracellular domain fragments, increased expression of proliferation-associated Notch targets, amplification of the Met/Caveolin locus, and elevated Met and Igf-1R signaling. Human BL breast tumors, commonly associated with JAGGED expression, elevated MET signaling, and CAVEOLIN accumulation, express low levels of LFNG. Thus, reduced LFNG expression facilitates JAG/NOTCH luminal progenitor signaling and cooperates with MET/CAVEOLIN basal-type signaling to promote BLBC. | - |
dc.format.extent | 24 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/10.1016/j.ccr.2012.03.041 | - |
dc.relation.ispartof | Cancer Cell, 2012, vol. 21, num. 5, p. 626-641 | - |
dc.relation.uri | http://dx.doi.org/10.1016/j.ccr.2012.03.041 | - |
dc.rights | (c) Elsevier, 2012 | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Càncer de mama | - |
dc.subject.classification | Expressió gènica | - |
dc.subject.classification | Transducció de senyal cel·lular | - |
dc.subject.classification | Proteïnes de membrana | - |
dc.subject.other | Breast cancer | - |
dc.subject.other | Gene expression | - |
dc.subject.other | Cellular signal transduction | - |
dc.subject.other | Membrane proteins | - |
dc.title | Lunatic Fringe Deficiency Cooperates with the Met/Caveolin Gene Amplicon to Induce Basal-Like Breast Cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 662596 | - |
dc.date.updated | 2016-10-05T07:54:32Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 22624713 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
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662596.pdf | 4.41 MB | Adobe PDF | View/Open |
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