Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/102886
Title: | Serotypes and Clonal Diversity of Streptococcus pneumoniae Causing Invasive Disease in the Era of PCV13 in Catalonia, Spain |
Author: | Amo Moran, Eva del Esteva, Cristina Hernández Bou, Susanna Galles, Carmen Navarro, Marian Sauca, Goretti Díaz Conradi, Álvaro Gassiot, Paula Marti, Carmina Larrosa, Nieves Ciruela, Pilar Jane, Mireia Sá-Leao, Raquel Muñoz-Almagro, Carmen García García, Juan José Catalan Study Group of Invasive Pneumococcal Disease [autoria conjunta] |
Keywords: | Pneumococs Vacunes Pneumònia Immunologia Espanya Catalunya Streptococcus pneumonia Vaccines Pneumonia Immunology Spain Catalonia |
Issue Date: | 8-Mar-2016 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | The aim of this study was to study the serotypes and clonal diversity of pneumococci causing invasive pneumococcal disease in Catalonia, Spain, in the era of 13-valent pneumococcal conjugate vaccine (PCV13). In our region, this vaccine is only available in the private market and it is estimated a PCV13 vaccine coverage around 55% in children. A total of 1551 pneumococcal invasive isolates received between 2010 and 2013 in the Molecular Microbiology Department at Hospital Sant Joan de Déu, Barcelona, were included. Fifty-two serotypes and 249 clonal types defined by MLST were identified. The most common serotypes were serotype 1 (n = 182; 11.7%), 3 (n = 145; 9.3%), 19A (n = 137; 8.8%) and 7F (n = 122; 7.9%). Serotype 14 was the third most frequent serotype in children < 2 years (15 of 159 isolates). PCV7 serotypes maintained their proportion along the period of study, 16.6% in 2010 to 13.4% in 2013, whereas there was a significant proportional decrease in PCV13 serotypes, 65.3% in 2010 to 48.9% in 2013 (p<0.01). This decrease was mainly attributable to serotypes 19A and 7F. Serotype 12F achieved the third position in 2013 (n = 22, 6.4%). The most frequent clonal types found were ST306 (n = 154, 9.9%), ST191 (n = 111, 7.2%), ST989 (n = 85, 5.5%) and ST180 (n = 80, 5.2%). Despite their decrease, PCV13 serotypes continue to be a major cause of disease in Spain. These results emphasize the need for complete PCV13 vaccination. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0151125 |
It is part of: | PLoS One, 2016, vol. 11, num. 3, p. e0151125 |
URI: | http://hdl.handle.net/2445/102886 |
Related resource: | http://dx.doi.org/10.1371/journal.pone.0151125 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
664604.pdf | 841.79 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License