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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/103103
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dc.contributor.authorRudilla Mateo, Héctor-
dc.contributor.authorFusté i Domínguez, Ester-
dc.contributor.authorCajal Visa, Yolanda-
dc.contributor.authorRabanal Anglada, Francesc-
dc.contributor.authorVinuesa Aumedes, Teresa-
dc.contributor.authorViñas, Miquel-
dc.date.accessioned2016-11-02T09:16:37Z-
dc.date.available2016-11-02T09:16:37Z-
dc.date.issued2016-09-12-
dc.identifier.issn1420-3049-
dc.identifier.urihttps://hdl.handle.net/2445/103103-
dc.description.abstractThe aim was to explore the antimicrobial activity of a synthetic peptide (AMP38) and its synergy with imipenem against imipenem-resistant Pseudomonas aeruginosa. The main mechanism of imipenem resistance is the loss or alteration of protein OprD. Time-kill and minimal biofilm eradication concentration (MBEC) determinations were carried out by using clinical imipenem-resistant strains. AMP38 was markedly synergistic with imipenem when determined in imipenem-resistant P. aeruginosa. MBEC obtained for the combination of AMP38 and imipenem was of 62.5 μg/mL, whereas the MBEC of each antimicrobial separately was 500 μg/mL. AMP38 should be regarded as a promising antimicrobial to fight MDR P. aeruginosa infections. Moreover, killing effect and antibiofilm activity of AMP38 plus imipenem was much higher than that of colistin plus imipenem.-
dc.format.extent12 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherMDPI-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3390/molecules21091223-
dc.relation.ispartofMolecules, 2016, vol. 21, num. 9, p. 1223-
dc.relation.urihttps://doi.org/10.3390/molecules21091223-
dc.rightscc-by (c) Rudilla, Héctor et al., 2016-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es-
dc.sourceArticles publicats en revistes (Patologia i Terapèutica Experimental)-
dc.subject.classificationPseudomonas-
dc.subject.classificationSíntesi de pèptids-
dc.subject.classificationPèptids-
dc.subject.classificationBiofilms-
dc.subject.classificationAntibiòtics-
dc.subject.otherPseudomonas-
dc.subject.otherPeptide synthesis-
dc.subject.otherPeptides-
dc.subject.otherBiofilms-
dc.subject.otherAntibiotics-
dc.titleSynergistic antipseudomonal effects of synthetic peptide AMP38 and carbapenems-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec663969-
dc.date.updated2016-11-02T09:16:42Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid27626405-
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Química Inorgànica i Orgànica)
Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)
Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB))
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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