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Title: Multiscale simulation of DNA
Author: Dans, Pablo D.
Walther, Jürgen
Gómez, Hansel
Orozco López, Modesto
Keywords: ADN
Àcids nucleics
Nucleic acids
Issue Date: 19-Dec-2015
Publisher: Elsevier
Abstract: DNA is not only among the most important molecules in life, but a meeting point for biology, physics and chemistry, being studied by numerous techniques. Theoretical methods can help in gaining a detailed understanding of DNA structure and function, but their practical use is hampered by the multiscale nature of this molecule. In this regard, the study of DNA covers a broad range of different topics, from sub-Angstrom details of the electronic distributions of nucleobases, to the mechanical properties of millimeter-long chromatin fibers. Some of the biological processes involving DNA occur in femtoseconds, while others require years. In this review, we describe the most recent theoretical methods that have been considered to study DNA, from the electron to the chromosome, enriching our knowledge on this fascinating molecule.
Note: Versió postprint del document publicat a:
It is part of: Current Opinion in Structural Biology, 2015, vol. 37, p. 29-45
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ISSN: 0959-440X
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
Publicacions de projectes de recerca finançats per la UE

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