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DC Field | Value | Language |
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dc.contributor.author | Oller Salvia, Benjamí | - |
dc.contributor.author | Sánchez Navarro, Macarena | - |
dc.contributor.author | Ciudad Fernández, Sonia | - |
dc.contributor.author | Guiu, Marc | - |
dc.contributor.author | Arranz Gibert, Pol | - |
dc.contributor.author | García, Cristina | - |
dc.contributor.author | Gomis i Cabré, Roger | - |
dc.contributor.author | Cecchelli, Roméo | - |
dc.contributor.author | García Arroyo, Jesús | - |
dc.contributor.author | Giralt Lledó, Ernest | - |
dc.contributor.author | Teixidó Turà, Meritxell | - |
dc.date.accessioned | 2016-11-14T08:29:57Z | - |
dc.date.available | 2016-11-14T08:29:57Z | - |
dc.date.issued | 2016-01-05 | - |
dc.identifier.issn | 0003-3022 | - |
dc.identifier.uri | http://hdl.handle.net/2445/103642 | - |
dc.description.abstract | Drug delivery across the blood-brain barrier (BBB) is a formidable challenge for therapies targeting the central nervous system. Although BBB shuttle peptides enhance transport into the brain non-invasively, their application is partly limited by lability to proteases. The present study proposes the use of cyclic peptides derived from venoms as an affordable way to circumvent this drawback. Apamin, a neurotoxin from bee venom, was minimized by reducing its complexity, toxicity, and immunogenicity, while preserving brain targeting, active transport, and protease resistance. Among the analogues designed, the monocyclic lactam-bridged peptidomimetic MiniAp-4 was the most permeable. This molecule is capable of translocating proteins and nanoparticles in a human-cell-based BBB model. Furthermore, MiniAp-4 can efficiently deliver a cargo across the BBB into the brain parenchyma of mice. | - |
dc.format.extent | 4 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1002/anie.201508445 | - |
dc.relation.ispartof | Angewandte Chemie International Edition, 2016, vol. 55, num. 2, p. 572-575 | - |
dc.relation.uri | https://doi.org/10.1002/anie.201508445 | - |
dc.rights | cc-by-nc-nd (c) Oller Salvia, Benjamí et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | Verins animals | - |
dc.subject.classification | Síntesi de pèptids | - |
dc.subject.classification | Malalties cerebrals | - |
dc.subject.other | Venom | - |
dc.subject.other | Peptide synthesis | - |
dc.subject.other | Brain diseases | - |
dc.title | MiniAp-4: A Venom-Inspired Peptidomimetic for Brain Delivery | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 657016 | - |
dc.date.updated | 2016-11-14T08:30:02Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26492861 | - |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
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File | Description | Size | Format | |
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657016.pdf | 2.84 MB | Adobe PDF | View/Open |
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