Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/103662
Title: | The role of the c-Jun N-terminal kinase (JNK) pathway in insulin resistance |
Author: | Caelles Franch, Carme Lanuza Masdeu, Jordi Arévalo, M. Isabel Díaz-Delfín, Julieta Morcillo, Melisa Bayod Giron, Carles |
Keywords: | Resistència a la insulina Obesitat Diabetis no-insulinodependent Insulin resistance Obesity Non-insulin-dependent diabetes |
Issue Date: | 2016 |
Publisher: | Research Signpost |
Abstract: | Obesity is usually associated with a decreased response to insulin, a major metabolic defect known as insulin resistance and an early trait in the development of type 2 diabetes. The c-Jun N-terminal kinase (JNK) pathway has emerged as a central regulator of insulin sensitivity, locally and systemically, thereby, of body’s metabolic homeostasis. As the incidence of obesity and type 2 diabetes has alarmingly increased in the last few decades, there is a tremendous necessity to identify novel pharmacological targets to efficiently improve the therapeutic outcome. In this regard, the JNK pathway seems to meet most of the requirements for being an adequate candidate to direct pharmacological intervention. |
Note: | Podeu consultar el llibre complet a: http://hdl.handle.net/2445/103042 |
Note: | Reproducció del capítol del llibre publicat a: http://www.trnres.com/ebookcontents.php?id=267 |
It is part of: | Recent Advances in Pharmaceutical Sciences VI, 2016, Research Signpost. Editors: Diego Muñoz Torrero, Àngela Domínguez García & Ma. Ángeles Manresa Presas. ISBN: 978-81-308-0566-5. Chapter 5, p. 76-90. |
URI: | http://hdl.handle.net/2445/103662 |
Related resource: | http://hdl.handle.net/2445/103042 |
Appears in Collections: | Llibres / Capítols de llibre (Bioquímica i Fisiologia) |
Files in This Item:
File | Description | Size | Format | |
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Capítol5.pdf | 382.7 kB | Adobe PDF | View/Open |
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