Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/103882
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tauriello, Daniele V. F. | - |
dc.contributor.author | Calon, Alexandre | - |
dc.contributor.author | Lonardo, Enza | - |
dc.contributor.author | Batlle, Eduard | - |
dc.date.accessioned | 2016-11-18T10:52:10Z | - |
dc.date.available | 2016-11-18T10:52:10Z | - |
dc.date.issued | 2016-10-28 | - |
dc.identifier.uri | http://hdl.handle.net/2445/103882 | - |
dc.description.abstract | Colorectal cancer (CRC) is one of the most common cancer types and represents a major therapeutic challenge. Although initial events in colorectal carcinogenesis are relatively well characterized and treatment for early‐stage disease has significantly improved over the last decades, the mechanisms underlying metastasis – the main cause of death – remain poorly understood. Correspondingly, no effective therapy is currently available for advanced or metastatic disease. There is increasing evidence that colorectal cancer is hierarchically organized and sustained by cancer stem cells, in concert with various stromal cell types. Here, we review the interplay between cancer stem cells and their microenvironment in promoting metastasis and discuss recent insights relating to both patient prognosis and novel targeted treatment strategies. A better understanding of these topics may aid the prevention or reduction of metastatic burden. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/10.1002/1878-0261.12018 | - |
dc.relation.ispartof | Molecular Oncology, 2016 | - |
dc.relation.uri | http://dx.doi.org/10.1002/1878-0261.12018 | - |
dc.rights | cc by (c) Tauriello et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Cèl·lules mare | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Stem cells | - |
dc.title | Determinants of metastatic competency in colorectal cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.date.updated | 2016-11-18T10:46:46Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28085225 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
This item is licensed under a Creative Commons License