Por favor, use este identificador para citar o enlazar este documento: https://hdl.handle.net/2445/103904
Título: Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery
Autor: Marques, Joana
Valle Delgado, Juan José
Urbán, Patricia
Baró, Elisabet
Prohens López, Rafael
Mayor Aparicio, Alfredo Gabriel
Cisteró, Pau
Delves, Michael
Sinden, Robert E.
Grandfils, Christian
Paz, José L. de
García Salcedo, José A.
Fernàndez Busquets, Xavier
Materia: Nanomedicina
Malària
Nanomedicine
Malaria
Fecha de publicación: 5-oct-2016
Publicado por: Elsevier
Resumen: The adaptation of existing antimalarial nanocarriers to new Plasmodium stages, drugs, targeting molecules, or encapsulating structures is a strategy that can provide new nanotechnology-based, cost-efficient therapies against malaria. We have explored the modification of different liposome prototypes that had been developed in our group for the targeted delivery of antimalarial drugs to Plasmodium-infected red blood cells (pRBCs). These new models include: (i) immunoliposome-mediated release of new lipid-based antimalarials; (ii) liposomes targeted to pRBCs with covalently linked heparin to reduce anticoagulation risks; (iii) adaptation of heparin to pRBC targeting of chitosan nanoparticles; (iv) use of heparin for the targeting of Plasmodium stages in the mosquito vector; and (v) use of the non-anticoagulant glycosaminoglycan chondroitin 4-sulfate as a heparin surrogate for pRBC targeting. The results presented indicate that the tuning of existing nanovessels to new malaria-related targets is a valid low-cost alternative to the de novo development of targeted nanosystems.
Nota: Versió postprint del document publicat a: http://dx.doi.org/10.1016/j.nano.2016.09.010
Es parte de: Nanomedicine: Nanotechnology, Biology, and Medicine, 2016
URI: https://hdl.handle.net/2445/103904
Recurso relacionado: http://dx.doi.org/10.1016/j.nano.2016.09.010
ISSN: 1549-9634
Aparece en las colecciones:Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB))
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

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