Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/104022
Title: | APOE-by-sex interactions on brain structure and metabolism in healthy elderly controls |
Author: | Sampedro, Frederic Vilaplana, Eduard De Leon, Mony J. Alcolea, Daniel Pegueroles, Jordi Montal, Victor Carmona-Iragui, Maria Sala, Isabel Sanchez-Saudinos, María Belén Antón-Aguirre, Sofía Morenas-Rodriguez, Estrella Camacho, Valle Falcon, Carles Pavía Segura, Javier Ros Puig, Domènec Clarimón, Jordi Blesa González, Rafael Lleó Bisa, Alberto Fortea Ormaechea, Juan Alzheimer's Disease Neuroimaging Initiative |
Keywords: | Malalties hereditàries Malaltia d'Alzheimer Proteïnes Lípids de la sang Envelliment Genetic diseases Alzheimer's disease Proteins Blood lipids Aging |
Issue Date: | 29-Sep-2015 |
Publisher: | Impact Journals |
Abstract: | BACKGROUND: The APOE effect on Alzheimer Disease (AD) risk is stronger in women than in men but its mechanisms have not been established. We assessed the APOE-by-sex interaction on core CSF biomarkers, brain metabolism and structure in healthy elderly control individuals (HC). METHODS: Cross-sectional study. HC from the Alzheimer's Disease Neuroimaging Initiative with available CSF (n = 274) and/or 3T-MRI (n = 168) and/or a FDG-PET analyses (n = 328) were selected. CSF amyloid-β1-42 (Aβ1-42), total-tau (t-tau) and phospho-tau (p-tau181p) levels were measured by Luminex assays. We analyzed the APOE-by-sex interaction on the CSF biomarkers in an analysis of covariance (ANCOVA). FDG uptake was analyzed by SPM8 and cortical thickness (CTh) was measured by FreeSurfer. FDG and CTh difference maps were derived from interaction and group analyses. RESULTS: APOE4 carriers had lower CSF Aβ1-42 and higher CSF p-tau181p values than non-carriers, but there was no APOE-by-sex interaction on CSF biomarkers. The APOE-by-sex interaction on brain metabolism and brain structure was significant. Sex stratification showed that female APOE4 carriers presented widespread brain hypometabolism and cortical thinning compared to female non-carriers whereas male APOE4 carriers showed only a small cluster of hypometabolism and regions of cortical thickening compared to male non-carriers. CONCLUSIONS: The impact of APOE4 on brain metabolism and structure is modified by sex. Female APOE4 carriers show greater hypometabolism and atrophy than male carriers. This APOE-by-sex interaction should be considered in clinical trials in preclinical AD where APOE4 status is a selection criterion. |
Note: | Reproducció del document publicat a: http://doi.org/10.18632/oncotarget.5185 |
It is part of: | Oncotarget, 2015, vol. 6, num. 29, p. 26663-26674 |
URI: | http://hdl.handle.net/2445/104022 |
Related resource: | http://doi.org/10.18632/oncotarget.5185 |
ISSN: | 1949-2553 |
Appears in Collections: | Articles publicats en revistes (Biomedicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
656978.pdf | 653.57 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License