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http://hdl.handle.net/2445/104289
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DC Field | Value | Language |
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dc.contributor.author | Abulí, Anna | - |
dc.contributor.author | Castells Garangou, Antoni | - |
dc.contributor.author | Bujanda, Luis | - |
dc.contributor.author | Lozano Salvatella, Juan José | - |
dc.contributor.author | Bessa i Caserras, Xavier | - |
dc.contributor.author | Hernández-Munain, Cristina | - |
dc.contributor.author | Álvarez Urturi, Cristina | - |
dc.contributor.author | Pellisé Urquiza, Maria | - |
dc.contributor.author | Esteban-Jurado, Clara | - |
dc.contributor.author | Hijona, Elizabeth | - |
dc.contributor.author | Burón, Andrea | - |
dc.contributor.author | Macià, Francesc | - |
dc.contributor.author | Grau Cano, J. (Jaume) | - |
dc.contributor.author | Guayta, Rafael (Guayta Escolies) | - |
dc.contributor.author | Castellví Bel, Sergi | - |
dc.contributor.author | Andreu, Montserrat | - |
dc.contributor.author | Trilla García, Antoni | - |
dc.contributor.author | PROCOLON Research Group | - |
dc.date.accessioned | 2016-11-30T09:34:27Z | - |
dc.date.available | 2016-11-30T09:34:27Z | - |
dc.date.issued | 2016-04-14 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/104289 | - |
dc.description.abstract | Background Common low-penetrance genetic variants have been consistently associated with colorec- tal cancer risk. Aim To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multi- plicity ( 3 adenomas). Methods We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorec- tal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. Results We found that 14 of the analyzed genetic variants showed a statistically significant associa- tion with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with 17 risk alleles. Conclusions Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a sub- group with increased risk for advanced neoplasia and/or multiplicity in the general population. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0153084 | - |
dc.relation.ispartof | PLoS One, 2016, vol. 11, num. 4, p. e0153084 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0153084 | - |
dc.rights | cc-by (c) Abulí, Anna et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Genètica humana | - |
dc.subject.classification | Estudi de casos | - |
dc.subject.classification | Mutació (Biologia) | - |
dc.subject.classification | Colonoscòpia | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Human genetics | - |
dc.subject.other | Case studies | - |
dc.subject.other | Mutation (Biology) | - |
dc.subject.other | Colonoscopy | - |
dc.title | Genetic Variants Associated with Colorectal Adenoma Susceptibility | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 664539 | - |
dc.date.updated | 2016-11-30T09:34:32Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27078840 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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664539.pdf | 376.5 kB | Adobe PDF | View/Open |
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