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Title: | FOXP1 molecular cytogenetics and protein expression analyses in primary cutaneous large B cell lymphoma, leg-type |
Author: | Espinet Solà, Blanca García Herrera, Adriana Gallardo, F. (Fernando) Baró, Cristina Salgado, Rocío Servitje Bedate, Octavio Estrach Panella, Ma. Teresa (María Teresa) Colomo Saperas, Lluís Romagosa, Vicenç Barranco, Carlos Serrano, Sergi Campo Güerri, Elias Pujol, Ramon M. Solé Ristol, Francesc |
Keywords: | Limfomes Pell Citogenètica Proteïnes Cèl·lules B Càncer de pell Lymphomas Skin Cytogenetics Proteins B cells Skin cancer |
Issue Date: | Feb-2011 |
Publisher: | Universidad de Murcia |
Abstract: | FOXP1 protein is expressed in normal activated B cells and overexpressed in a subset of diffuse large B-cell lymphomas, including primary cutaneous large B-cell lymphomas (PCLBCL), leg type. High expression of FOXP1 has been associated to an unfavourable prognosis with independent survival significance. However, little is known regarding the mechanisms underlying the overexpression of FOXP1 in PCLBCL, leg type. Our aims were to analyze FOXP1 cytogenetic status and protein expression in a series of PCLBCL, leg type. Finally, we compared the observed results with those obtained in a group of patients with primary cutaneous follicle centre lymphoma (PCFCL). Fifteen patients with PCLBCL, leg type and nine patients with primary cutaneous follicle centre lymphoma (PCFCL) were included in the study. For each biopsy specimen, FOXP1 translocation and copy number changes were evaluated by fluorescence in situ hybridization (FISH) and protein expression by immunohistochemistry (IHC). Immunohistochemistry showed FOXP1 staining in 13 PCLBCL, leg type, whereas all PCFCL were negative. FISH analysis disclosed no translocations involving FOXP1 gene in any of the cases. However, FOXP1 gene gains (3 to 4 copies) were observed in 82% of samples of PCLBCL, leg type and in 37% of PCFCL. FOXP1 expression was independent from FOXP1 translocation. Our results confirm that overexpression of FOXP1 is present in a considerable proportion of PCLBCL, leg type and might indicate an unfavourable prognosis. Mechanisms not related to translocation seem to be responsible for this overexpression. |
Note: | Reproducció del document publicat a: https://digitum.um.es/xmlui/bitstream/10201/47804/1/Espinet-26-213-221-2011.pdf |
It is part of: | Histology and Histopathology, 2011, vol. 26, num. 2, p. 213-221 |
URI: | http://hdl.handle.net/2445/104342 |
ISSN: | 0213-3911 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Fonaments Clínics) Articles publicats en revistes (Medicina) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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