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http://hdl.handle.net/2445/104407
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DC Field | Value | Language |
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dc.contributor.author | Rosato, Valentina | - |
dc.contributor.author | Tavani, Alessandra | - |
dc.contributor.author | Gracia Lavedan, Esther | - |
dc.contributor.author | Guinó, Elisabet | - |
dc.contributor.author | Castaño-Vinyals, Gemma | - |
dc.contributor.author | Villanueva, Cristina M. | - |
dc.contributor.author | Kogevinas, Manolis | - |
dc.contributor.author | Polesel, Jerry | - |
dc.contributor.author | Serraino, Diego | - |
dc.contributor.author | Pisa, Federica E. | - |
dc.contributor.author | Barbone, Fabio | - |
dc.contributor.author | Moreno Aguado, Víctor | - |
dc.contributor.author | La Vecchia, Carlo | - |
dc.contributor.author | Bosetti, Cristina | - |
dc.date.accessioned | 2016-12-02T12:14:47Z | - |
dc.date.available | 2016-12-02T12:14:47Z | - |
dc.date.issued | 2016-10-06 | - |
dc.identifier.issn | 2234-943X | - |
dc.identifier.uri | http://hdl.handle.net/2445/104407 | - |
dc.description.abstract | Background: type 2 diabetes mellitus has been associated with an excess risk of colorectal cancer, although the time-risk relationship is unclear, and there is limited information on the role of antidiabetic medications. Aim: we examined the association between type 2 diabetes, antidiabetic medications, and the risk of colorectal cancer, considering also duration of exposures. Methods: we analyzed data derived from two companion case-control studies conducted in Italy and Spain between 2007 and 2013 on 1,147 histologically confirmed colorectal cancer cases and 1,594 corresponding controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by unconditional multiple logistic regression models, adjusted for socioeconomic factors and major potential confounding factors. Results: overall, 14% of cases and 12% of controls reported a diagnosis of diabetes, corresponding to an OR of colorectal cancer of 1.21 (95% CI 0.95-1.55). The OR was 1.49 (95% CI 0.97-2.29) for a duration of diabetes of at least 15 years. The OR was 1.53 (95% CI 1.06-2.19) for proximal colon cancer, 0.94 (95% CI 0.66-1.36) for distal colon cancer, and 1.32 (95% CI 0.94-1.87) for rectal cancer. In comparison with no use, metformin use was associated with a decreased colorectal cancer risk (OR 0.47, 95% CI 0.24-0.92), while insulin use was associated with an increased risk (OR 2.20, 95% CI 1.12-4.33); these associations were stronger for longer use (OR 0.36 and 8.18 for ≥10 years of use of metformin and insulin, respectively). Conclusion: this study shows evidence of a positive association between diabetes and colorectal cancer, mainly proximal colon cancer. Moreover, it indicates a negative association between colorectal cancer and metformin use and a positive association for insulin use. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3389/fonc.2016.00210 | - |
dc.relation.ispartof | Frontiers in Oncology, 2016, vol. 6, p. 210 | - |
dc.relation.uri | https://doi.org/10.3389/fonc.2016.00210 | - |
dc.rights | cc-by (c) Rosato, Valentina et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Antidiabètics | - |
dc.subject.classification | Diabetis | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Insulina | - |
dc.subject.classification | Metformina | - |
dc.subject.classification | Factors de risc en les malalties | - |
dc.subject.classification | Itàlia | - |
dc.subject.classification | Espanya | - |
dc.subject.other | Hypoglucemic agents | - |
dc.subject.other | Diabetes | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Insulin | - |
dc.subject.other | Metformin | - |
dc.subject.other | Risk factors in diseases | - |
dc.subject.other | Italy | - |
dc.subject.other | Spain | - |
dc.title | Type 2 diabetes, antidiabetic medications, and colorectal cancer risk: two case-control studies from Italy and Spain | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 665147 | - |
dc.date.updated | 2016-12-02T12:14:52Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27766252 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (ISGlobal) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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