Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/104424
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Reyes-Zurita, Fernando J. | - |
dc.contributor.author | Rufino Palomares, Eva E. | - |
dc.contributor.author | García Salguero, Leticia | - |
dc.contributor.author | Peragón, Juan | - |
dc.contributor.author | Medina, Pedro P. | - |
dc.contributor.author | Parra Puerto, Andrés | - |
dc.contributor.author | Cascante i Serratosa, Marta | - |
dc.contributor.author | Lupiáñez, José A. | - |
dc.date.accessioned | 2016-12-02T15:43:05Z | - |
dc.date.available | 2016-12-02T15:43:05Z | - |
dc.date.issued | 2016-01-11 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/104424 | - |
dc.description.abstract | Maslinic acid (MA) is a natural triterpene present in high concentrations in the waxy skin of olives. We have previously reported that MA induces apoptotic cell death via the mito- chondrial apoptotic pathway in HT29 colon cancer cells. Here, we show that MA induces apoptosis in Caco-2 colon cancer cells via the extrinsic apoptotic pathway in a dose- dependent manner. MA triggered a series of effects associated with apoptosis, including the cleavage of caspases -8 and -3, and increased the levels of t-Bid within a few hours of its addition to the culture medium. MA had no effect on the expression of the Bax protein, release of cytochrome-c or on the mitochondr ial membrane potential. This suggests that MA triggered the extrinsic apoptotic pathway in this cell type, as opposed to the intrinsic pathway found in the HT29 colon-cancer cell line. Our results suggest that the apoptotic mechanism induced in Caco-2 may be different from that found in HT29 colon-cancer cells, and that in Caco-2 cells MA seems to work independently of p53. Natural antitumoral agents capable of activating both the extrinsic and intrinsic apoptotic pathways could be of great use in treating colon-cancer of whatever origin. | - |
dc.format.extent | 16 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0146178 | - |
dc.relation.ispartof | PLoS One, 2016, vol. 11, num. 1, p. e0146178 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0146178 | - |
dc.rights | cc-by (c) Reyes-Zurita, Fernando J. et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Olis vegetals | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Diferenciació cel·lular | - |
dc.subject.classification | Proteïnes | - |
dc.subject.other | Vegetable oils | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Cell diferentiation | - |
dc.subject.other | Proteins | - |
dc.title | Maslinic acid, a natural Triterpene, induces a death receptor-mediated apoptotic mechanism in Caco-2 p53-deficient colon adenocarcinoma cells | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 656271 | - |
dc.date.updated | 2016-12-02T15:43:11Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26751572 | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
656271.pdf | 2.22 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License