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http://hdl.handle.net/2445/104526
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DC Field | Value | Language |
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dc.contributor.author | Ulloa Darquea, Fausto Alexander | - |
dc.contributor.author | Gonzàlez Juncà, Alba | - |
dc.contributor.author | Meffre, Delphine | - |
dc.contributor.author | Barrecheguren Manero, Pablo José | - |
dc.contributor.author | Martínez Mármol, Ramón | - |
dc.contributor.author | Pazos Capell, Irene | - |
dc.contributor.author | Olivé, Núria | - |
dc.contributor.author | Cotrufo, Tiziana | - |
dc.contributor.author | Seoane Suárez, Joan | - |
dc.contributor.author | Soriano García, Eduardo | - |
dc.date.accessioned | 2016-12-07T14:13:57Z | - |
dc.date.available | 2016-12-07T14:13:57Z | - |
dc.date.issued | 2015-03-24 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/104526 | - |
dc.description.abstract | Glioblastoma (GBM) is the most prevalent adult brain tumor, with virtually no cure, and with a median overall survival of 15 months from diagnosis despite of the treatment. SNARE pro- teins mediate membrane fusion events in cells and are essential for many cellular process- es including exocytosis and neurotransmission, intracellular trafficking and cell migration. Here we show that the blockade of the SNARE protein Syntaxin 1 (Stx1) function impairs GBM cell proliferation. We show that Stx1 loss-of-function in GBM cells, through ShRNA lentiviral transduction, a Stx1 dominant negative and botulinum toxins, dramatically reduces the growth of GBM after grafting U373 cells into the brain of immune compromised mice. In- terestingly, Stx1 role on GBM progression may not be restricted just to cell proliferation since the blockade of Stx1 also reduces in vitro GBM cell invasiveness suggesting a role in several processes relevant for tumor progression. Altogether, our findings indicate that the blockade of SNARE proteins may represent a novel therapeutic tool against GBM. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0119707 | - |
dc.relation.ispartof | PLoS One, 2015, vol. 10, num. 3, p. e0119707 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0119707 | - |
dc.rights | cc-by (c) Ulloa et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) | - |
dc.subject.classification | Proteïnes citosquelètiques | - |
dc.subject.classification | Tumors | - |
dc.subject.classification | Glioma | - |
dc.subject.other | Cytoskeletal proteins | - |
dc.subject.other | Tumors | - |
dc.subject.other | Gliomas | - |
dc.title | Blockade of the SNARE protein syntaxin 1 inhibits glioblastoma tumor growth | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 643134 | - |
dc.date.updated | 2016-12-07T14:14:02Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25803850 | - |
Appears in Collections: | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) |
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643134.pdf | 982.8 kB | Adobe PDF | View/Open |
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