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Title: | Predictors of severe sepsis among patients hospitalized for community-acquired pneumonia |
Author: | Montull, Beatriz Menéndez, Rosario Torres Martí, Antoni Reyes, Soledad Méndez, Raúl Zalacaín, Rafael Capelastegui, Alberto Rajas, Olga Borderías, Luis Martín Villasclaras, Juan Bello, Salvador Alfageme, Inmaculada Rodríguez de Castro, Felipe Rello Condomines, Jordi Molinos, Luis Ruiz Manzano, Juan |
Keywords: | Septicèmia Malalties pulmonars obstructives cròniques Pneumònia Antibiòtics Septicemia Chronic obstructive pulmonary diseases Pneumonia Antibiotics |
Issue Date: | 4-Jan-2016 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Background Severe sepsis, may be present on hospital arrival in approximately one-third of patients with community-acquired pneumonia (CAP). Objective To determine the host characteristics and micro-organisms associated with severe sepsis in patients hospitalized with CAP. Results We performed a prospective multicenter cohort study in 13 Spanish hospital, on 4070 hospi- talized CAP patients, 1529 of whom (37.6%) presented with severe sepsis. Severe sepsis CAP was independently associated with older age ( > 65 years), alcohol abuse (OR, 1.31; 95% CI, 1.07 - 1.61), chronic obstructive pulmonary disease (COPD) (OR, 1.75; 95% CI, 1.50 - 2.04) and renal disease (OR, 1.57; 95% CI, 1.21 - 2.03), whereas prior antibiotic treat- ment was a protective factor (OR, 0.62; 95% CI, 0.52 - 0.73). Bacteremia (OR, 1.37; 95% CI, 1.05 - 1.79), S pneumoniae (OR, 1.59; 95% CI, 1.31 - 1.95) and mixed microbial etiology (OR, 1.65; 95% CI, 1.10 - 2.49) were associated with severe sepsis CAP. Conclusions CAP patients with COPD, renal disease and alcohol abuse, as well as those with CAP due to S pneumonia or mixed micro-organisms are more likely to present to the hospital with severe sepsis. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0145929 |
It is part of: | PLoS One, 2016, vol. 11, num. 1, p. e0145929 |
URI: | http://hdl.handle.net/2445/105203 |
Related resource: | https://doi.org/10.1371/journal.pone.0145929 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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