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Title: | No differences of immune activation and microbial translocation among HIV-infected children receiving combined antiretroviral therapy or protease inhibitor monotherapy. |
Author: | Falcon Neyra, Lola Benmarzouk-Hidalgo, Omar J. Madrid, Lola Noguera Julian, Antoni Fortuny Guasch, Claudia Neth, Olaf López Cortés, Luis F. |
Keywords: | Infants Infeccions per VIH Antiretrovirals Inhibidors enzimàtics Children HIV infections Antiretroviral agents Enzyme inhibitors |
Issue Date: | Mar-2015 |
Publisher: | Lippincott, Williams & Wilkins. Wolters Kluwer Health |
Abstract: | This is a cross-sectional study of 15 aviremic chronic HIV-infected children revealing no differences in immune activation (IA; HLA-DRCD38 CD4 and CD8 T cells, and sCD14) and microbial translocation (MT; lipopolysaccharides (LPS) and 16S rDNA) among HIV-infected patients under combined antiretroviral treatment (cART; n = 10) or ritonavir-boosted protease inhibitor monotherapy (mtPI/rtv; n = 5). In both cases, IA and MT were lower in healthy control children (n = 32). This observational study suggests that ritonavir boosted protease inhibitor monotherapy (mtPI/rtv) is not associated with an increased state of IA or MT as compared with children receiving cART. |
Note: | Reproducció del document publicat a: https://doi.org/10.1097/MD.0000000000000521 |
It is part of: | Medicine, 2015, vol. 94, num. 11, p. e521 |
URI: | http://hdl.handle.net/2445/105795 |
Related resource: | https://doi.org/10.1097/MD.0000000000000521 |
ISSN: | 0025-7974 |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (ISGlobal) |
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