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Title: | Metabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess. |
Author: | Samino Gené, Sara Vinaixa Crevillent, Maria Díaz, Marta Beltran, Antoni Rodríguez, Miguel Angel Mallol, Roger Heras, Mercedes Cabré Llobet, Anna García, Lorena Canela i Canela, Núria Zegher, Francis de Correig Blanchar, Xavier Ibáñez Toda, Lourdes Yanes, Oscar |
Keywords: | Adolescents Andrògens Hormones sexuals Lipoproteïnes de la sang Teenagers Androgens Sex hormones Blood lipoproteins |
Issue Date: | 23-Jun-2015 |
Publisher: | Nature Publishing Group |
Abstract: | Hyperinsulinaemic androgen excess (HIAE) in prepubertal and pubertal girls usually precedes a broader pathological phenotype in adulthood that is associated with anovulatory infertility, metabolic syndrome and type 2 diabetes. The metabolic derangements that determine these long-term health risks remain to be clarified. Here we use NMR and MS-based metabolomics to show that serum levels of methionine sulfoxide in HIAE girls are an indicator of the degree of oxidation of methionine-148 residue in apolipoprotein-A1. Oxidation of apo-A1 in methionine-148, in turn, leads to an impaired maturation of high-density lipoproteins (HDL) that is reflected in a decline of large HDL particles. Notably, such metabolic alterations occur in the absence of impaired glucose tolerance, hyperglycemia and hypertriglyceridemia, and were partially restored after 18 months of treatment with a low-dose combination of pioglitazone, metformin and flutamide. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/srep11496 |
It is part of: | Scientific Reports, 2015, vol. 5, p. 11496 |
URI: | http://hdl.handle.net/2445/105867 |
Related resource: | https://doi.org/10.1038/srep11496 |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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