Association between long telomere length and insulin sensitization in adolescent girls with hyperinsulinemic androgen excess

Abstract

The centile of telomere length from early adulthood until senescence is mainly set between early gestation and adolescence.1 Hyperinsulinemic androgen excess (HIAE) is the most prevalent endocrinopathy of adolescent girls and is frequently driven by an absolute or relative excess of fat.2 Hyperinsulinemic androgen excess in adolescence is associated with a higher risk for a broad range of endocrine, metabolic, and cardiovascular complications later in life.3