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http://hdl.handle.net/2445/107169
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DC Field | Value | Language |
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dc.contributor.author | Potrony Mateu, Míriam | - |
dc.contributor.author | Carreras Margalef, Esther | - |
dc.contributor.author | Aranda, Fernando | - |
dc.contributor.author | Zimmer, Lisa | - |
dc.contributor.author | Puig Butillé, Joan Anton | - |
dc.contributor.author | Tell Martí, Gemma | - |
dc.contributor.author | Armiger Borràs, Noelia | - |
dc.contributor.author | Sucker, Antje | - |
dc.contributor.author | Gimenez-Xavier, Pol | - |
dc.contributor.author | Martínez-Florensa, Mario | - |
dc.contributor.author | Carrera Álvarez, Cristina | - |
dc.contributor.author | Malvehy, J. (Josep) | - |
dc.contributor.author | Schadendorf, Dirk | - |
dc.contributor.author | Puig i Sardà, Susana | - |
dc.contributor.author | Lozano Soto, Francisco | - |
dc.date.accessioned | 2017-02-20T17:27:31Z | - |
dc.date.available | 2017-09-15T22:01:22Z | - |
dc.date.issued | 2016-09-15 | - |
dc.identifier.issn | 0020-7136 | - |
dc.identifier.uri | http://hdl.handle.net/2445/107169 | - |
dc.description.abstract | Despite the recent progress in treatment options, malignant melanoma remains a deadly disease. Besides therapy, inherited factors might modulate clinical outcome, explaining in part widely varying survival rates. T-cell effector function regulators on antitumor immune responses could also influence survival. CD5, a T-cell receptor inhibitory molecule, contributes to the modulation of antimelanoma immune responses as deduced from genetically modified mouse models. The CD5 SNPs rs2241002 (NM_014207.3:c.671C > T, p.Pro224Leu) and rs2229177 (NM_014207.3:c.1412C > T, p.Ala471Val) constitute an ancestral haplotype (Pro224-Ala471) that confers T-cell hyper-responsiveness and worsens clinical autoimmune outcome. The assessment of these SNPs on survival impact from two melanoma patient cohorts (Barcelona, N = 493 and Essen, N = 215) reveals that p.Ala471 correlates with a better outcome (OR= 0.57, 95% CI = 0.33-0.99, Adj. p = 0.043, in Barcelona OR = 0.63, 95% CI = 0.40-1.01, Adj. p = 0.051, in Essen). While, p.Leu224 was associated with increased melanoma-associated mortality in both cohorts (OR = 1.87, 95% CI = 1.07-3.24, Adj. p = 0.030 in Barcelona and OR = 1.84, 95% CI = 1.04-3.26, Adj. p = 0.037, in Essen). Furthermore survival analyses showed that the Pro224-Ala471 haplotype in homozygosis improved melanoma survival in the entire set of patients (HR = 0.27, 95% CI 0.11-0.67, Adj. p = 0.005). These findings highlight the relevance of genetic variability in immune-related genes for clinical outcome in melanoma. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1002/ijc.30184 | - |
dc.relation.ispartof | International Journal of Cancer, 2016, vol. 139, num. 6, p. 1297-1302 | - |
dc.relation.uri | https://doi.org/10.1002/ijc.30184 | - |
dc.rights | (c) Union for International Cancer Control (UICC), 2016 | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Melanoma | - |
dc.subject.classification | Receptors cel·lulars | - |
dc.subject.classification | Oncologia | - |
dc.subject.other | Melanoma | - |
dc.subject.other | Cell receptors | - |
dc.subject.other | Oncology | - |
dc.title | Inherited functional variants of the lymphocyte receptor CD5 influence melanoma survival | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 667669 | - |
dc.date.updated | 2017-02-20T17:27:31Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27169428 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (Biomedicina) |
Files in This Item:
File | Description | Size | Format | |
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667669.pdf | 219.34 kB | Adobe PDF | View/Open |
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