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DC Field | Value | Language |
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dc.contributor.author | Pérez Bosque, Anna | - |
dc.contributor.author | Miró Martí, Ma. Lluïsa | - |
dc.contributor.author | Amat, Concepció | - |
dc.contributor.author | Polo Pozo, Francisco Javier | - |
dc.contributor.author | Moretó, Miquel, 1950- | - |
dc.date.accessioned | 2017-02-20T17:51:16Z | - |
dc.date.available | 2017-02-20T17:51:16Z | - |
dc.date.issued | 2016-10-02 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | http://hdl.handle.net/2445/107173 | - |
dc.description.abstract | Spray-dried preparations from porcine and bovine plasma can alleviate mucosal inflammation in experimental models and improve symptoms in patients with enteropathy. In rodents, dietary supplementation with porcine spray-dried plasma (SDP) attenuates intestinal inflammation and improves the epithelial barrier function during intestinal inflammation induced by Staphylococcus aureus enterotoxin B (SEB). The aim of this study was to discern the molecular mechanisms involved in the anti-inflammatory effects of SDP. Male C57BL/6 mice were fed with 8% SDP or control diet (based on milk proteins) for two weeks, from weaning until day 33. On day 32, the mice were given a SEB dose (i.p., 25 µg/mouse) or vehicle. SEB administration increased cell recruitment to mesenteric lymph nodes and the percentage of activated Th lymphocytes and SDP prevented these effects). SDP supplementation increased the expression of interleukin 10 (IL-10) or transforming growth factor- β (TGF-β) compared to the SEB group. The SEB challenge increased six-fold the expression of mucosal addressin cell adhesion molecule 1 (MAdCAM-1) and intercellular adhesion molecule 1 (ICAM-1); and these effects were attenuated by SDP supplementation. SEB also augmented NF-κB phosphorylation, an effect that was prevented by dietary SDP. Our results indicate that the anti-inflammatory effects of SDP involve the regulation of transcription factors and adhesion molecules that reduce intestinal cell infiltration and the degree of the inflammatory response. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/nu8100657 | - |
dc.relation.ispartof | Nutrients, 2016, vol. 8, num. 10, p. pii: E65 | - |
dc.relation.uri | https://doi.org/10.3390/nu8100657 | - |
dc.rights | cc-by (c) Pérez Bosque, Anna et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Bioquímica i Fisiologia) | - |
dc.subject.classification | Inflamació | - |
dc.subject.classification | Intestins | - |
dc.subject.classification | Factors de transcripció | - |
dc.subject.classification | Suplements nutritius | - |
dc.subject.other | Inflammation | - |
dc.subject.other | Intestines | - |
dc.subject.other | Transcription factors | - |
dc.subject.other | Dietary supplements | - |
dc.title | The Anti-inflammatory effect of spray-dried plasma is mediated by a reduction in mucosal lymphocyte activation and infiltration in a mouse model of intestinal inflammation. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 664986 | - |
dc.date.updated | 2017-02-20T17:51:16Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27782068 | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Fisiologia) |
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664986.pdf | 2.92 MB | Adobe PDF | View/Open |
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