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https://hdl.handle.net/2445/107804| Title: | Impact of the functional CD5 polymorphism A471V on the response of chronic lymphocytic leukaemia to conventional chemotherapy regimens. |
| Author: | Delgado, Julio (Delgado González) Bielig, Torsten Bonet, Lizette Carnero Montoro, Elena Puente, Xose S. Colomer Pujol, Dolors Bosch, Elena Campo Güerri, Elias Lozano Soto, Francisco |
| Keywords: | Leucèmia limfocítica crònica Receptors cel·lulars Cèl·lules B Biologia molecular Immunologia Chronic lymphocytic leukemia Cell receptors B cells Molecular biology Immunology |
| Issue Date: | 15-Mar-2016 |
| Publisher: | Blackwell Science |
| Abstract: | Chronic lymphocytic leukaemia (CLL) represents an abnormal clonal expansion of mature antigen-experienced CD5+ B1a cells (Chiorazzi et al, 2005), which present with a highly heterogeneous clinical course depending on associated chromosomal aberrations, somatic mutations within the immunoglobulin variable heavy chain genes (IGHV), and surface CD38 or intracytoplasmic ZAP-70 expression. Given that key signalling components of the B-cell receptor (BCR) are relevant contributors to the variable clinical behaviour of CLL (Stevenson et al, 2011) we explored the influence of functionally relevant germline CD5 variants on CLL prognosis. |
| Note: | https://doi.org/10.1111/bjh.14037 |
| It is part of: | British Journal of Haematology, 2017, vol. 177,num. 1,p. 147-150 |
| URI: | https://hdl.handle.net/2445/107804 |
| Related resource: | https://doi.org/10.1111/bjh.14037 |
| ISSN: | 0007-1048 |
| Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
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