Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/108046
Title: | Stereocontrolled access to enantiopure to enantiopure 7-substituted cis- and trans-octahydroindoles |
Author: | Ghirardi, Elena Griera Farres, Rosa Piccichè, Miriam Molins i Grau, Elies Fernández Cadenas, Israel Bosch Cartes, Joan Amat Tusón, Mercedes |
Keywords: | Lactames Síntesi asimètrica Lactams Asymmetric synthesis |
Issue Date: | 18-Nov-2016 |
Publisher: | American Chemical Society |
Abstract: | Cyclocondensation of (R)-phenylglycinol with stereoisomeric mixtures (racemates, cis/trans) of 3-substituted 2- oxocyclohexaneacetates stereoselectively afforded tricyclic oxazoloindolone lactams, from which straightforward procedures for the stereocontrolled formation of enantiopure 7-substituted octahydroindoles with a variety of stereochemical patterns have been developed. The methodology has been successfully applied to the synthesis of (+)-α-lycorane. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1021/acs.orglett.6b02861 |
It is part of: | Organic Letters, 2016, vol. 18, num. 22, p. 5836-5839 |
URI: | http://hdl.handle.net/2445/108046 |
Related resource: | https://doi.org/10.1021/acs.orglett.6b02861 |
ISSN: | 1523-7060 |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
664992.pdf | 480.47 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.