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Title: PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia
Author: Ola, Roxana
Dubrac, Alexandre
Han, Jinah
Zhang, Feng
Fang, Jennifer S.
Larrivée, Bruno
Lee, Monica
Urarte, Ana A.
Kraehling, Jan R.
Genet, Gael
Hirschi, Karen K.
Sessa, William C.
Viñals Canals, Francesc
Graupera i Garcia-Milà, Mariona
Yan, Minhong
Young, Lawrence H.
Oh, Paul S.
Eichmann, Anne
Keywords: Malalties vasculars
Rates (Animals de laboratori)
Proteïnes quinases
Vascular diseases
Rats as laboratory animals
Protein kinases
Issue Date: 29-Nov-2016
Publisher: Nature Publishing Group
Abstract: Activin receptor-like kinase 1 (ALK1) is an endothelial serine-threonine kinase receptor for bone morphogenetic proteins (BMPs) 9 and 10. Inactivating mutations in the ALK1 gene cause hereditary haemorrhagic telangiectasia type 2 (HHT2), a disabling disease characterized by excessive angiogenesis with arteriovenous malformations (AVMs). Here we show that inducible, endothelial-specific homozygous Alk1 inactivation and BMP9/10 ligand blockade both lead to AVM formation in postnatal retinal vessels and internal organs including the gastrointestinal (GI) tract in mice. VEGF and PI3K/AKT signalling are increased on Alk1 deletion and BMP9/10 ligand blockade. Genetic deletion of the signal-transducing Vegfr2 receptor prevents excessive angiogenesis but does not fully revert AVM formation. In contrast, pharmacological PI3K inhibition efficiently prevents AVM formation and reverts established AVMs. Thus, Alk1 deletion leads to increased endothelial PI3K pathway activation that may be a novel target for the treatment of vascular lesions in HHT2.
Note: Reproducció del document publicat a:
It is part of: Nature Communications, 2016, vol. 7, num. 13650, p. 1-12
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ISSN: 2041-1723
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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