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http://hdl.handle.net/2445/108816
Title: | Associations between gender, disease features and symptom burden in the MPN population: An analysis by the MPN QOL International Working Group |
Author: | Geyer, Holly L. Kosiorek, Heidi Dueck, Amylou C. Scherber, Robyn Slot, Stefanie Zweegman, Sonja Te Boekhorst, Peter A. Senyak, Zhenya Schouten, Harry C. Sackmann, Federico Kerguelen Fuentes, Ana Hernández-Maraver, Dolores Pahl, Heike L. Griesshammer, Martin Stegelmann, Frank Döhner, Konstanze Lehmann, Thomas Bonatz, Karin Reiter, Andreas Boyer, Francoise Etienne, Gabriel Ianotto, Jean-Christophe Ranta, Dana Roy, Lydia Cahn, Jean-Yves Harrison, Claire N. Radia, Deepti Muxi, Pablo Maldonado, Norman Besses, Carlos Cervantes Requena, F. Johansson, Peter L. Barbui, Tiziano Barosi, Giovanni Vannucchi, Alessandro M. Paoli, Chiara Passamonti, Francesco Andreasson, Bjorn Ferrari, Maria L. Rambaldi, Alessandro Samuelsson, Jan Cannon, Keith Birgegard, Gunnar Xiao, Zhijian Xu, Zefeng Zhang, Yue Sun, Xiujuan Xu, Junqing Kiladjian, Jean-Jacques Zhang, Peihong Gale, Robert Peter Mesa, Ruben A. |
Keywords: | Factors sexuals en les malalties Trastorns de les plaquetes sanguínies Mielomatosi Sex factors in disease Blood platelet disorders Myeloproliferative disorders |
Issue Date: | 1-Jan-2017 |
Publisher: | Ferrata Storti Foundation |
Abstract: | The myeloproliferative neoplasms, including polycythemia vera, essential thrombocythemia and myelofibrosis, are distinguished by their debilitating symptom profiles, life-threatening complications and profound impact on quality of life. The role gender plays in the symptomatology of myeloproliferative neoplasms remains under-investigated. In this study we evaluated how gender relates to patients' characteristics, disease complications and overall symptom expression. A total of 2,006 patients (polycythemia vera=711, essential thrombocythemia=830, myelofibrosis=460, unknown=5) were prospectively evaluated, with patients completing the Myeloproliferative Neoplasm-Symptom Assessment Form and Brief Fatigue Inventory Patient Reported Outcome tools. Information on the individual patients' characteristics, disease complications and laboratory data was collected. Consistent with known literature, most female patients were more likely to have essential thrombocythemia (48.6% versus 33.0%; P<0.001) and most male patients were more likely to have polycythemia vera (41.8% versus 30.3%; P<0.001). The rate of thrombocytopenia was higher among males than females (13.9% versus 8.2%; P<0.001) and males also had greater red-blood cell transfusion requirements (7.3% versus 4.9%; P=0.02) with shorter mean disease duration (6.4 versus 7.2 years, P=0.03). Despite there being no statistical differences in risk scores, receipt of most therapies or prior complications (hemorrhage, thrombosis), females had more severe and more frequent symptoms for most individual symptoms, along with overall total symptom score (22.8 versus 20.3; P<0.001). Females had particularly high scores for abdominal-related symptoms (abdominal pain/discomfort) and microvascular symptoms (headache, fatigue, insomnia, concentration difficulties, dizziness; all P<0.01). Despite complaining of more severe symptom burden, females had similar quality of life scores to those of males. The results of this study suggest that gender contributes to the heterogeneity of myeloproliferative neoplasms by influencing phenotypic profiles and symptom expression. |
Note: | Reproducció del document publicat a: https://doi.org/10.3324/haematol.2016.149559 |
It is part of: | Haematologica, 2017, vol. 102, num. 1, p. 85-93 |
URI: | http://hdl.handle.net/2445/108816 |
Related resource: | https://doi.org/10.3324/haematol.2016.149559 |
ISSN: | 0390-6078 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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