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http://hdl.handle.net/2445/108856
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DC Field | Value | Language |
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dc.contributor.author | Álvarez Larrán, Alberto | - |
dc.contributor.author | Pereira Saavedra, Arturo | - |
dc.contributor.author | Guglielmelli, Paola | - |
dc.contributor.author | Hernández Boluda, Juan Carlos | - |
dc.contributor.author | Arellano Rodrigo, Eduardo | - |
dc.contributor.author | Ferrer Marín, Francisca | - |
dc.contributor.author | Samah, Alimam | - |
dc.contributor.author | Griesshammer, Martin | - |
dc.contributor.author | Kerguelen Fuentes, Ana | - |
dc.contributor.author | Andreasson, Bjorn | - |
dc.contributor.author | Burgaleta, Carmen | - |
dc.contributor.author | Schwarz, Jiri | - |
dc.contributor.author | García Gutiérrez, Valentín | - |
dc.contributor.author | Ayala, Rosa | - |
dc.contributor.author | Barba, Pere | - |
dc.contributor.author | Gómez Casares, María Teresa | - |
dc.contributor.author | Paoli, Chiara | - |
dc.contributor.author | Drexler, Beatrice | - |
dc.contributor.author | Zweegman, Sonja | - |
dc.contributor.author | McMullin, Mary F. | - |
dc.contributor.author | Samuelsson, Jan | - |
dc.contributor.author | Harrison, Claire N. | - |
dc.contributor.author | Cervantes Requena, F. | - |
dc.contributor.author | Vannucchi, Alessandro M. | - |
dc.contributor.author | Besses, Carlos | - |
dc.date.accessioned | 2017-03-23T17:37:35Z | - |
dc.date.available | 2017-03-23T17:37:35Z | - |
dc.date.issued | 2016-08-01 | - |
dc.identifier.issn | 0390-6078 | - |
dc.identifier.uri | http://hdl.handle.net/2445/108856 | - |
dc.description.abstract | The role of antiplatelet therapy as primary prophylaxis of thrombosis in low-risk essential thrombocythemia has not been studied in randomized clinical trials. We assessed the benefit/risk of lowdose aspirin in 433 patients with low-risk essential thrombocythemia (271 with a CALR mutation, 162 with a JAK2V617F mutation) who were on antiplatelet therapy or observation only. After a follow up of 2215 person- years free from cytoreduction, 25 thrombotic and 17 bleeding episodes were recorded. In CALR-mutated patients, antiplatelet therapy did not affect the risk of thrombosis but was associated with a higher incidence of bleeding (12.9 versus 1.8 episodes per 1000 patient-years, P=0.03). In JAK2V617F-mutated patients, low-dose aspirin was associated with a reduced incidence of venous thrombosis with no effect on the risk of bleeding. Coexistence of JAK2V617F-mutation and cardiovascular risk factors increased the risk of thrombosis, even after adjusting for treatment with low-dose aspirin (incidence rate ratio: 9.8; 95% confidence interval: 2.3-42.3; P=0.02). Time free from cytoreduction was significantly shorter in CALR-mutated patients with essential thrombocythemia than in JAK2V617F-mutated ones (median time 5 years and 9.8 years, respectively; P=0.0002) and cytoreduction was usually necessary to control extreme thrombocytosis. In conclusion, in patients with low-risk, CALR-mutated essential thrombocythemia, low-dose aspirin does not reduce the risk of thrombosis and may increase the risk of bleeding. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Ferrata Storti Foundation | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3324/haematol.2016.146654 | - |
dc.relation.ispartof | Haematologica, 2016, vol. 101, num. 8, p. 926-931 | - |
dc.relation.uri | https://doi.org/10.3324/haematol.2016.146654 | - |
dc.rights | (c) Ferrata Storti Foundation, 2016 | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Trombosi | - |
dc.subject.classification | Plaquetes sanguínies | - |
dc.subject.classification | Malalties hematològiques | - |
dc.subject.other | Thrombosis | - |
dc.subject.other | Blood platelets | - |
dc.subject.other | Hematologic diseases | - |
dc.title | Antiplatelet therapy versus observation in low-risk essential thrombocythemia with CALR mutation | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 669558 | - |
dc.date.updated | 2017-03-23T17:37:35Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27175028 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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File | Description | Size | Format | |
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669558.pdf | 842.44 kB | Adobe PDF | View/Open |
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