Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/109424
Title: | Estimation of renal function by CKD-EPI versus MDRD in a cohort of HIV-infected patients: a cross-sectional analysis. |
Author: | Cristelli, M. P. Cofán Pujol, Federico Rico, N. Trullás Vila, Joan Carles Manzardo, Christian Agüero Santangelo, Fernando Bedini, J. L. Moreno Camacho, Ma. Asunción Oppenheimer Salinas, Federico Miró Meda, José M. |
Keywords: | VIH (Virus) Persones seropositives Malalties del ronyó Nefrologia HIV (Viruses) HIV-positive persons Kidney diseases Nephrology |
Issue Date: | 10-Feb-2017 |
Publisher: | BioMed Central |
Abstract: | Background Accurately determining renal function is essential for clinical management of HIV patients. Classically, it has been evaluated by estimating glomerular filtration rate (eGFR) with the MDRD-equation, but today there is evidence that the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation has greater diagnostic accuracy. To date, however, little information exists on patients with HIV-infection. This study aimed to evaluate eGFR by CKD-EPI vs. MDRD equations and to stratify renal function according to KDIGO guidelines. Methods Cross-sectional, single center study including adult patients with HIV-infection. Results Four thousand five hundred three patients with HIV-infection (864 women; 19%) were examined. Median age was 45 years (IQR 37-52), and median baseline creatinine was 0.93 mg/dL (IQR 0.82-1.05). A similar distribution of absolute measures of eGFR was found using both formulas (p = 0.548). Baseline median eGFR was 95.2 and 90.4 mL/min/1.73 m2 for CKD-EPI and MDRD equations (p < 0.001), respectively. Of the 4503 measurements, 4109 (91.2%) agreed, with a kappa index of 0.803. MDRD classified 7.3% of patients as "mild reduced GFR" who were classified as "normal function" with CKD-EPI. Using CKD-EPI, it was possible to identify "normal function" (>90 mL/min/1.73 m2) in 73% patients and "mild reduced GFR" (60-89 mL/min/1.73 m2) in 24.3% of the patients, formerly classified as >60 mL/min/1.73 m2 with MDRD. Conclusions There was good correlation between CKD-EPI and MDRD. Estimating renal function using CKD-EPI equation allowed better staging of renal function and should be considered the method of choice. CKD-EPI identified a significant proportion of patients (24%) with mild reduced GFR (60-89 mL/min/1.73 m2). |
Note: | Reproducció del document publicat a: https://doi.org/10.1186/s12882-017-0470-4 |
It is part of: | BMC Nephrology, 2017, vol. 18, num. 1, p. 58 |
URI: | http://hdl.handle.net/2445/109424 |
Related resource: | https://doi.org/10.1186/s12882-017-0470-4 |
ISSN: | 1471-2369 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
669001.pdf | 627.19 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License