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Title: | Positron emission tomography assessment of large vessel inflammation in patients with newly diagnosed, biopsy-proven giant cell arteritis: a prospective, case-control study |
Author: | Prieto González, Sergio Depetris, Marina García Martínez, Ana Espígol Frigolé, Georgina Tavera Bahillo, Itziar Corbera Bellalta, Marc Planas Rigol, Ester Alba Garibay, Marco Antonio Hernández Rodríguez, José Grau Junyent, Josep M. (Josep Maria) Lomeña Caballero, Francisco Juan Cid Xutglà, M. Cinta |
Keywords: | Arteritis de cèl·lules gegants Càncer Inflamació Tomografia computada per emissió de fotó simple Estudi de casos Giant cell arteritis Cancer Inflammation Single-photon emission computed tomography Case studies |
Issue Date: | 1-Jul-2014 |
Publisher: | BMJ Publishing Group |
Abstract: | BACKGROUND: Positron emission tomography (PET) scan is emerging as a promising imaging technique to detect large-vessel inflammation in giant cell arteritis (GCA). However, the lack of a standardised definition of arteritis based on (18)fluorodeoxyglucose (FDG) uptake is an important limitation to the use of PET scan for diagnostic purposes. OBJECTIVE: To prospectively assess the intensity and distribution of FDG uptake at different vascular territories in patients with newly diagnosed GCA compared with controls. METHODS: 32 consecutive, biopsy-proven, GCA patients treated with glucocorticoids for ≤3 days were included. The control group consisted of 20 individuals, who underwent PET/CT for cancer staging. Maximal standardised uptake value (SUVm) was calculated at four aortic segments, supraaortic branches and iliac-femoral territory. Sensitivity and specificity was calculated by receiver-operator characteristic curves (ROC) analysis. RESULTS: Mean SUVm was significantly higher in patients than in controls in all vessels explored and correlated with acute-phase reactants and serum IL-6. Mean of the SUVm at all the vascular territories had an area under the curve (AUC) of 0.830, and a cut-off of 1.89 yielded a sensitivity of 80% and a specificity of 79% for GCA diagnosis. There were no significant differences in AUC among the vascular beds examined. CONCLUSIONS: FDG uptake by large vessels has a substantial sensitivity and specificity for GCA diagnosis. |
Note: | Reproducció del document publicat a: https://doi.org/10.1136/annrheumdis-2013-204572 |
It is part of: | Annals of the Rheumatic Diseases, 2014, vol. 73, num. 7, p. 1388-1392 |
URI: | http://hdl.handle.net/2445/109782 |
Related resource: | https://doi.org/10.1136/annrheumdis-2013-204572 |
ISSN: | 0003-4967 |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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