Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/109785
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Aviñó Andrés, Anna | - |
dc.contributor.author | Dellafiore, Maria | - |
dc.contributor.author | Gargallo Gómez, Raimundo | - |
dc.contributor.author | González, Carlos | - |
dc.contributor.author | Iribarren, Adolfo M. | - |
dc.contributor.author | Montserrat, Javier | - |
dc.contributor.author | Eritja i Casadellà, Ramon | - |
dc.date.accessioned | 2017-04-19T11:23:44Z | - |
dc.date.available | 2018-04-13T22:01:20Z | - |
dc.date.issued | 2017-04-13 | - |
dc.identifier.issn | 1439-4227 | - |
dc.identifier.uri | http://hdl.handle.net/2445/109785 | - |
dc.description.abstract | G-quadruplex and i-motif are tetraplex structures present in telomeres and promoter regions of oncogenes. The possibility of producing nanodevices with pH-sensitive functions has triggered the interest for modified oligonucleotides with improved structural properties. We synthesized C-rich oligonucleotides carrying conformationally restricted (2'S)-2'-deoxy-2'-C-methyl-cytidine units. The effect of this modified nucleoside on the stability of intramolecular i-motifs related to vertebrate telomere was investigated by means of spectroscopic methods (UV, CD and NMR). The replacement of selected positions of the C-core by the appropriate C-modified residues induces the formation of stable intercalated tetraplexes at pHs near neutrality. The study demonstrates the possibility of enhancing the stability of i-motif by chemical modifications. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-VCH | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1002/cbic.201700112 | - |
dc.relation.ispartof | ChemBioChem, 2017 | - |
dc.relation.uri | https://doi.org/10.1002/cbic.201700112 | - |
dc.rights | (c) Wiley-VCH, 2017 | - |
dc.source | Articles publicats en revistes (Enginyeria Química i Química Analítica) | - |
dc.subject.classification | Àcids nucleics | - |
dc.subject.classification | Oligonucleòtids | - |
dc.subject.classification | G-estructures | - |
dc.subject.other | Nucleic acids | - |
dc.subject.other | Oligonucleotides | - |
dc.subject.other | G-structures | - |
dc.title | Stabilization of telomeric i-motif structures by (2'S)-2'-deoxy-2'-C-methyl-cytidine residues | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 671009 | - |
dc.date.updated | 2017-04-19T11:23:44Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28407336 | - |
Appears in Collections: | Articles publicats en revistes (Enginyeria Química i Química Analítica) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
671009.pdf | 985.22 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.