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Title: Plasmodium vivax gametocytes in the bone marrow of an acute malaria patient and changes in the erythroid miRNA profile
Author: Baro, Barbara
Deroost, Katrien
Raiol, Tainá
Brito, Marcelo A. M.
Almeida, Anne Cristine Gomes
Menezes Neto, Armando de
Figueiredo, Erick F. G.
Alencar, Aline
Leitao, Rodrigo
Val, Fernando
Monteiro, Wuelton Marcelo
Oliveira, Anna
Armengol, Maria del Pilar
Fernández-Becerra, Carmen
Lacerda, Marcus Vinícius Guimarães
Portillo Obando, Hernando A. del
Keywords: Plasmodium vivax
Plasmodium vivax
Issue Date: 6-Apr-2017
Publisher: Public Library of Science (PLoS)
Abstract: Plasmodium vivax is the most widely distributed human malaria parasite and responsible for large amounts of disease and burden [1]. The presence of P. vivax in the bone marrow was first noticed in the late 19th century [2], and examinations of sternal bone marrow aspirates were performed as an accessory to examinations of peripheral blood in malaria, including P. vivax [3]. Since then, little progress has been made in studying P. vivax infections in this tissue. One report explored accumulation of dyserythropoietic cells in anaemic infected patients [4]. In addition, two case studies reported P. vivax infections after autologous bone marrow transplantation [5][6], and a third one documented an accidental P. vivax infection due to bone marrow transplantation between a malaria-infected donor and a malaria-free receptor [7]. In Brazil, one patient with persistent thrombocytopaenia and an enlarged spleen was diagnosed with chronic P. vivax malaria after the finding of schizonts in the bone marrow aspirate [8]. In all these reports and case studies, however, parasite loads and life stages found in the bone marrow were not investigated, and no molecular tools were available to rule out mixed infections or to characterize specific parasite stages.
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It is part of: PLoS Neglected Tropical Diseases, 2017, vol. 11, num. 4, p. e0005365
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ISSN: 1935-2727
Appears in Collections:Articles publicats en revistes (ISGlobal)

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