Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/110442
Title: | Coassembly and coupling of SK2 channels and mGlu5 receptors |
Author: | García-Negredo, Gloria Soto del Cerro, David Llorente, Javier Morató Arús, Xavier Galenkamp, Koen M.O. Gómez Soler, Maricel Fernández Dueñas, Víctor Watanabe, Masahiko Adelman, John P. Shigemoto, Ryuichi Fukazawa, Yugo Luján, Rafael Ciruela Alférez, Francisco |
Keywords: | Canals de potassi Neurologia Hipocamp (Cervell) Farmacologia Rates (Animals de laboratori) Potassium channels Neurology Hippocampus (Brain) Pharmacology Rats as laboratory animals |
Issue Date: | 29-Oct-2014 |
Publisher: | The Society for Neuroscience |
Abstract: | Group I metabotropic glutamate (mGlu) receptors regulate hippocampal CA1 pyramidal neuron excitability via Ca(2+) wave-dependent activation of small-conductance Ca(2+)-activated K(+) (SK) channels. Here, we show that mGlu5 receptors and SK2 channels coassemble in heterologous coexpression systems and in rat brain. Further, in cotransfected cells or rat primary hippocampal neurons, mGlu5 receptor stimulation activated apamin-sensitive SK2-mediated K(+) currents. In addition, coexpression of mGlu5 receptors and SK2 channels promoted plasma membrane targeting of both proteins and correlated with increased mGlu5 receptor function that was unexpectedly blocked by apamin. These results demonstrate a reciprocal functional interaction between mGlu5 receptors and SK2 channels that reflects their molecular coassembly. |
Note: | Reproducció del document publicat a: https://doi.org/10.1523/JNEUROSCI.2038-14.2014 |
It is part of: | Journal of Neuroscience, 2014, vol. 34, num. 44, p. 14793-14802 |
URI: | http://hdl.handle.net/2445/110442 |
Related resource: | https://doi.org/10.1523/JNEUROSCI.2038-14.2014 |
ISSN: | 0270-6474 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Biomedicina) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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