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Title: Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease
Author: Sanchez-Mut, Jose Vicente
Aso Pérez, Ester
Heyn, Holger
Matsuda, Tadashi
Bock, Christoph
Ferrer, Isidro (Ferrer Abizanda)
Esteller, Manel
Keywords: Epigènesi
Hipocamp (Cervell)
Malaltia d'Alzheimer
Malalties neurodegeneratives
Hippocampus (Brain)
Alzheimer's disease
Neurodegenerative Diseases
Issue Date: Apr-2014
Publisher: Wiley
Abstract: Genetic screening in Alzheimer's disease (AD) has identified only a handful of genes that are mutated in the disorder. Thus, for a very large proportion of patients, the biology of their disease is poorly understood. Epigenetic alterations may provide an explanation in these cases. Using DNA methylation profiles of human hippocampus from controls and patients, we have identified the presence of promoter hypermethylation of the dual-specificity phosphatase 22 (DUSP22) gene in AD. DUSP22 is a likely candidate gene for involvement in the pathogenesis of the disorder since, as we demonstrate here, it inhibits PKA activity and thereby determines TAU phosphorylation status and CREB signaling.
Note: Reproducció del document publicat a:
It is part of: Hippocampus, 2014, vol. 24, num. 4, p. 363-368
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ISSN: 1050-9631
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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