Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/111110
Title: | In vivo conditional deletion of HDAC7 reveals its requirement to establish proper B lymphocyte identity and development |
Author: | Azagra Rodríguez, Alba Román González, Lidia Collazo, Olga Rodríguez Ubreva, Javier Yébenes, Virginia G. de Barneda Zahonero, Bruna Rodríguez Lumbiarres, Jairo, 1980- Castro de Moura, Manuel Grego Bessa, Joaquim Fernández Duran, Irene Islam, Abul B. M. M. K. Esteller, Manel Ramiro, Almudena R. Ballestar Tarín, Esteban Parra Bola, Mª Isabel |
Keywords: | Cèl·lules B Histones Limfòcits Gens Proteïnes B cells Histones Lymphocytes Genes Proteins |
Issue Date: | Nov-2016 |
Publisher: | Rockefeller University Press |
Abstract: | Class IIa histone deacetylase (HDAC) subfamily members are tissue-specific gene repressors with crucial roles in development and differentiation processes. A prominent example is HDAC7, a class IIa HDAC that shows a lymphoid-specific expression pattern within the hematopoietic system. In this study, we explored its potential role in B cell development by generating a conditional knockout mouse model. Our study demonstrates for the first time that HDAC7 deletion dramatically blocks early B cell development and gives rise to a severe lymphopenia in peripheral organs, while also leading to pro-B cell lineage promiscuity. We find that HDAC7 represses myeloid and T lymphocyte genes in B cell progenitors through interaction with myocyte enhancer factor 2C (MEFC2). In B cell progenitors, HDAC7 is recruited to promoters and enhancers of target genes, and its absence leads to increased enrichment of histone active marks. Our results prove that HDAC7 is a bona fide transcriptional repressor essential for B cell development. |
Note: | Reproducció del document publicat a: https://doi.org/10.1084/jem.20150821 |
It is part of: | Journal of Experimental Medicine, 2016, vol. 213, num. 12, p. 2591-2601 |
URI: | http://hdl.handle.net/2445/111110 |
Related resource: | https://doi.org/10.1084/jem.20150821 |
ISSN: | 0022-1007 |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
669675.pdf | 2.22 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.