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DC Field | Value | Language |
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dc.contributor.author | Sambola Ayala, Antonia | - |
dc.contributor.author | Mutuberría, Maria | - |
dc.contributor.author | García del Blanco, Bruno | - |
dc.contributor.author | Alonso, Albert | - |
dc.contributor.author | Barrabés, José A. | - |
dc.contributor.author | Bueno, Héctor | - |
dc.contributor.author | Alfonso, Fernando | - |
dc.contributor.author | Cequier Fillat, Àngel R. | - |
dc.contributor.author | Zueco, Javier | - |
dc.contributor.author | Rodríguez-Leor, Oriol | - |
dc.contributor.author | Tornos, Pilar | - |
dc.contributor.author | García Dorado, David | - |
dc.date.accessioned | 2017-05-17T08:13:59Z | - |
dc.date.available | 2017-05-17T08:13:59Z | - |
dc.date.issued | 2016-01-25 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/111147 | - |
dc.description.abstract | Background and Purpose: Selecting an ideal antithrombotic therapy for elderly patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) can be challenging since they have a higher thromboembolic and bleeding risk than younger patients. The current study aimed to assess the efficacy and safety of triple therapy (TT: oral anticoagulation plus dual antiplate- let therapy: aspirin plus clopidogrel) in patients > 75 years of age with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI). Methods: A prospective multicenter study was conducted from 2003 to 2012 at 6 Spanish teaching hospitals. A cohort study of consecutive patients with AF undergoing PCI and treated with TT or dual antiplatelet therapy (DAPT) was analyzed. All outcomes were evaluated at 1- year of follow-up. Results: Five hundred and eighty-five patients, 289 (49%) of whom were > 75 years of age (79.6 ± 3.4 years; 33% women) were identified. TT was prescribed in 55.9% of patients at discharge who had a higher thromboembolic risk (CHA 2 DS 2 VASc score: 4.23 ± 1.51 vs 3.76 ± 1.40, p = 0.007 and a higher bleeding risk (HAS-BLED > 3: 88.6% vs 79.2%, p = 0.02) than those on DAPT. Therefore, patients on TT had a lower rate of thromboembolism than those on DAPT (0.6% vs 6.9%, p = 0.004; HR 0.08, 95% CI: 0.01 - 0.70, p = 0.004). Major bleeding events occurred more frequently in patients on TT than in those on DAPT (11.7% vs 2.4%, p = 0.002; HR 5.2, 95% CI: 1.53 - 17.57, p = 0.008). The overall mortality rate was similar in both treatment groups (11.9% vs 13.9%, p = 0.38); however, after adjustment for confounding variables, TT was associated with a reduced mortality rate (HR 0.33, 95% CI: 0.12 - 0.86, p = 0.02). Conclusions In elderly patients with AF undergoing PCI, the use of TT compared to DAPT was associ- ated with reduced thromboembolism and mortality rates, although a higher rate of major bleeding. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0147245 | - |
dc.relation.ispartof | PLoS One, 2016, vol. 11, num. 1, p. e0147245 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0147245 | - |
dc.rights | cc-by (c) Sambola Ayala, Antonia et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Persones grans | - |
dc.subject.classification | Fibril·lació auricular | - |
dc.subject.classification | Malalties coronàries | - |
dc.subject.classification | Cirurgia cardiovascular | - |
dc.subject.classification | Malalties de les persones grans | - |
dc.subject.other | Older people | - |
dc.subject.other | Atrial fibrillation | - |
dc.subject.other | Coronary diseases | - |
dc.subject.other | Cardiovascular surgery | - |
dc.subject.other | Older people diseases | - |
dc.title | Impact of triple therapy in elderly patients with atrial fibrillation undergoing percutaneous coronary intervention | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 662831 | - |
dc.date.updated | 2017-05-17T08:13:59Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26808678 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) |
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