Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/111398
Title: | Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns |
Author: | Sanchez-Mut, Jose Vicente Heyn, Holger Vidal, Enrique Moran, Sebastian Sayols, Sergi Delgado-Morales, Raul Schultz, Matthew D. Ansoleaga, Belén Garcia Esparcia, Paula Pons-Espinal, Meritxell Lagran, M. M. de Dopazo, Joaquín Rabano, Alberto Avila, Jesús Dierssen, Mara Lott, I. Ferrer, Isidro (Ferrer Abizanda) Ecker, Joseph R. Esteller, Manel |
Keywords: | Epigènesi ADN Metilació Malalties neurodegeneratives Sistema nerviós Epigenesis DNA Methylation Neurodegenerative Diseases Nervous system |
Issue Date: | 19-Jan-2016 |
Publisher: | Nature Publishing Group |
Abstract: | Different neurodegenerative disorders often show similar lesions, such as the presence of amyloid plaques, TAU-neurotangles and synuclein inclusions. The genetically inherited forms are rare, so we wondered whether shared epigenetic aberrations, such as those affecting DNA methylation, might also exist. The studied samples were gray matter samples from the prefrontal cortex of control and neurodegenerative disease-associated cases. We performed the DNA methylation analyses of Alzheimer's disease, dementia with Lewy bodies, Parkinson's disease and Alzheimer-like neurodegenerative profile associated with Down's syndrome samples. The DNA methylation landscapes obtained show that neurodegenerative diseases share similar aberrant CpG methylation shifts targeting a defined gene set. Our findings suggest that neurodegenerative disorders might have similar pathogenetic mechanisms that subsequently evolve into different clinical entities. The identified aberrant DNA methylation changes can be used as biomarkers of the disorders and as potential new targets for the development of new therapies. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/tp.2015.214 |
It is part of: | Translational Psychiatry, 2016, vol. 6, p. e718 |
URI: | http://hdl.handle.net/2445/111398 |
Related resource: | https://doi.org/10.1038/tp.2015.214 |
ISSN: | 2158-3188 |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Publicacions de projectes de recerca finançats per la UE |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
662706.pdf | 3.29 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License