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http://hdl.handle.net/2445/111642
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DC Field | Value | Language |
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dc.contributor.author | Gómez Acebo, Inés | - |
dc.contributor.author | Dierssen Sotos, Trinidad | - |
dc.contributor.author | Palazuelos-Calderón, Camilo | - |
dc.contributor.author | Pérez Gómez, Beatriz | - |
dc.contributor.author | Lope, Virginia | - |
dc.contributor.author | Tusquets, Ignasi | - |
dc.contributor.author | Alonso Aguado, Maria Henar | - |
dc.contributor.author | Moreno Aguado, Víctor | - |
dc.contributor.author | Amiano, Pilar | - |
dc.contributor.author | Molina de la Torre, Antonio José | - |
dc.contributor.author | Barricarte, Aurelio | - |
dc.contributor.author | Tardón, Adonina | - |
dc.contributor.author | Camacho, Antonio | - |
dc.contributor.author | Peiró Pérez, Rosana | - |
dc.contributor.author | Marcos Gragera, Rafael | - |
dc.contributor.author | Muñoz, Montse | - |
dc.contributor.author | Michelena Echeveste, Maria Jesús | - |
dc.contributor.author | Ortega Valin, Luis | - |
dc.contributor.author | Guevara, Marcela | - |
dc.contributor.author | Castaño-Vinyals, Gemma | - |
dc.contributor.author | Aragonès Sanz, Núria | - |
dc.contributor.author | Kogevinas, Manolis | - |
dc.contributor.author | Pollán, Marina | - |
dc.contributor.author | Llorca Díaz, Javier | - |
dc.date.accessioned | 2017-05-29T08:20:41Z | - |
dc.date.available | 2017-05-29T08:20:41Z | - |
dc.date.issued | 2016-08-10 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/111642 | - |
dc.description.abstract | INTRODUCTION: The evidence on the relationship between breast cancer and different types of antihypertensive drugs taken for at least 5 years is limited and inconsistent. Furthermore, the debate has recently been fueled again with new data reporting an increased risk of breast cancer among women with a long history of use of antihypertensive drugs compared with nonusers. METHODS: In this case-control study, we report the antihypertensive drugs-breast cancer relationship in 1,736 breast cancer cases and 1,895 healthy controls; results are reported stratifying by the women's characteristics (i.e., menopausal status or body mass index category) tumor characteristics and length of use of antihypertensive drugs. RESULTS: The relationship among breast cancer and use of calcium channel blockers (CCB) for 5 or more years had odds ratio (OR) = 1.77 (95% CI, 0.99 to 3.17). Stratifying by BMI, the OR increased significantly in the group with BMI ≥ 25 (OR 2.54, 95% CI, 1.24 to 5.22). CCBs were even more strongly associated with more aggressive tumors, (OR for invasive tumors = 1.96, 95% CI = 1.09 to 3.53; OR for non ductal cancers = 3.97, 95% CI = 1.73 to 9.05; OR for Erbb2+ cancer = 2.97, 95% CI: 1.20 to 7.32). On the other hand, premenopausal women were the only group in which angiotensin II receptor blockers may be associated with breast cancer (OR = 4.27, 95% CI = 1.32 to 13.84) but this could not be identified with any type or stage. Use of angiotensin-converting-enzyme inhibitors, beta blockers and diuretics were not associated with risk. CONCLUSIONS: In this large population-based study we found that long term use of calcium channel blockers is associated with some subtypes of breast cancer (and with breast cancer in overweight women). | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0159672 | - |
dc.relation.ispartof | PLoS One, 2016, vol. 11, num. 8, p. e0159672 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0159672 | - |
dc.rights | cc-by (c) Gómez-Acebo, Ines et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Càncer de mama | - |
dc.subject.classification | Hormones | - |
dc.subject.classification | Hormonoteràpia | - |
dc.subject.classification | Oncologia | - |
dc.subject.classification | Canals de calci | - |
dc.subject.other | Breast cancer | - |
dc.subject.other | Hormones | - |
dc.subject.other | Hormone therapy | - |
dc.subject.other | Oncology | - |
dc.subject.other | Calcium channels | - |
dc.title | The Use of Antihypertensive Medication and the Risk of Breast Cancer in a Case-Control Study in a Spanish Population: The MCC-Spain Study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 665137 | - |
dc.date.updated | 2017-05-29T08:20:41Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27508297 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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665137.pdf | 223.94 kB | Adobe PDF | View/Open |
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