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Title: A serum microRNA signature associated with complete remission and progression after autologous stem-cell transplantation in patients with multiple myeloma
Author: Navarro Ponz, Alfons
Díaz Sánchez, Tania
Tovar, Natalia
Pedrosa, Fabiola
Tejero Villalba, Rut
Cibeira, María Teresa
Magnano, Laura
Rosiñol, Laura
Monzó Planella, Mariano
Bladé, J. (Joan)
Fernández de Larrea Rodríguez, Carlos José
Keywords: Micro RNAs
Trasplantament d'òrgans
Myeloproliferative disorders
Transplantation of organs
Issue Date: 30-Jan-2015
Publisher: Impact Journals
Abstract: We have examined serum microRNA expression in multiple myeloma (MM) patients at diagnosis and at complete response (CR) after autologous stem-cell transplantation (ASCT), in patients with stable monoclonal gammopathy of undetermined significance, and in healthy controls. MicroRNAs were first profiled using TaqMan Human MicroRNA Arrays. Differentially expressed microRNAs were then validated by individual TaqMan MicroRNA assays and correlated with CR and progression-free survival (PFS) after ASCT. Supervised analysis identified a differentially expressed 14-microRNA signature. The differential expression of miR-16 (P = 0.028), miR-17 (P = 0.016), miR-19b (P = 0.009), miR-20a (P = 0.017) and miR-660 (P = 0.048) at diagnosis and CR was then confirmed by individual assays. In addition, high levels of miR-25 were related to the presence of oligoclonal bands (P = 0.002). Longer PFS after ASCT was observed in patients with high levels of miR-19b (6 vs. 1.8 years; P < 0.001) or miR-331 (8.6 vs. 2.9 years; P = 0.001). Low expression of both miR-19b and miR-331 in combination was a marker of shorter PFS (HR 5.3; P = 0.033). We have identified a serum microRNA signature with potential as a diagnostic and prognostic tool in MM.
Note: Reproducció del document publicat a:
It is part of: Oncotarget, 2014, vol. 6, num. 3, p. 1874-1883
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ISSN: 1949-2553
Appears in Collections:Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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