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DC Field | Value | Language |
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dc.contributor.author | Ortiz, Fernanda | - |
dc.contributor.author | Gelpi, Rosana | - |
dc.contributor.author | Helanterä, Ilkka | - |
dc.contributor.author | Melilli, Edoardo | - |
dc.contributor.author | Honkanen, Eero | - |
dc.contributor.author | Bestard Matamoros, Oriol | - |
dc.contributor.author | Grinyó Boira, Josep M. | - |
dc.contributor.author | Cruzado, Josep Ma. | - |
dc.date.accessioned | 2017-06-06T11:04:37Z | - |
dc.date.available | 2017-06-06T11:04:37Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/112003 | - |
dc.description.abstract | Introduction The pros and cons for implementing protocol biopsies (PB) after kidney transplantation are still a matter of debate. We aimed to address the frequency of pathological findings in PB, to analyze their impact on long-term graft survival (GS) and to analyze the risk factors predicting an abnormal histology. Methods We analyzed 946 kidney PB obtained at a median time of 6.5 (±2.9) months after transplantation. Statistics included comparison between groups, Kaplan-Meier and multinomial logistic regression analysis. Results and Discussion PB diagnosis were: 53.4% normal; 46% IFTA; 12.3% borderline and 4.9% had subclinical acute rejection (SCAR). Inflammation had the strongest negative impact on GS. Therefore we split the cases into: "normal without inflammation", "normal with inflammation", "IFTA without inflammation", "IFTA with inflammation" and "rejection" (including SCAR and borderline). 15-year GS in PB diagnosed normal with inflammation was significantly decreased in a similar fashion as in rejection cases. Among normal biopsies, inflammation increased significantly the risk of 15-y graft loss (P = 0.01). Variables that predicted an abnormal biopsy were proteinuria, previous AR and DR-mismatch. Conclusion We conclude that inflammation in normal PB is associated with a significantly lower 15-y GS, comparable to rejection or IFTA with inflammation. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0159717 | - |
dc.relation.ispartof | PLoS One, 2016, vol. 11, num. 8, p. e0159717 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0159717 | - |
dc.rights | cc-by (c) Ortiz, Fernanda et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Inflamació | - |
dc.subject.classification | Biòpsia | - |
dc.subject.classification | Histologia | - |
dc.subject.other | Inflammation | - |
dc.subject.other | Biopsy | - |
dc.subject.other | Histology | - |
dc.title | Decreased kidney graft survival in low immunological risk patients showing inflammation in normal protocol biopsies | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 665165 | - |
dc.date.updated | 2017-06-06T11:04:37Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27532630 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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